Literature DB >> 10224341

Synthesis and screening for anti-HIV activity of some N-Mannich bases of isatin derivatives.

S N Pandeya1, P Yogeeswari, D Sriram, E de Clercq, C Pannecouque, M Witvrouw.   

Abstract

The effect of about 12 new compounds of Mannich bases of isatin against HIV-1 (IIIB) and HIV-2 (ROD) strains in MT 4 cells was studied. The screening method employed was MTT. In initial studies, one compound has shown maximum protection of 16% in subtoxic concentration.

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Year:  1999        PMID： 10224341     DOI： 10.1159/000007182

Source DB:  PubMed          Journal:  Chemotherapy        ISSN： 0009-3157            Impact factor:   2.544


  9 in total

1.  Synthesis, antibacterial, antifungal and antiviral activity evaluation of some new bis-Schiff bases of isatin and their derivatives.

Authors:  Aliasghar Jarrahpour; Dariush Khalili; Erik De Clercq; Chanaz Salmi; Jean Michel Brunel
Journal:  Molecules       Date:  2007-08-07       Impact factor: 4.411

2.  Computational studies of metal carbonyl complexes of 3[4-ethyl(phenly)imino][indoline-2-one] and 3[4-butyl(phenly)imino][indoline-2-one].

Authors:  Nursel Acar; Sevil Şener
Journal:  J Mol Model       Date:  2018-06-22       Impact factor: 1.810

3.  Design, synthesis, and antimicrobial screening of novel pyridyl-2-amidrazone incorporated isatin mannich bases.

Authors:  N Saravana Kumar; T Pradeep; G Jani; Divya Silpa; B Vijaya Kumar
Journal:  J Adv Pharm Technol Res       Date:  2012-01

4.  Design, Synthesis and antiHIV activity of Novel Isatine-Sulphonamides.

Authors:  P Selvam; N Murugesh; M Chandramohan; Z Debyser; M Witvrouw
Journal:  Indian J Pharm Sci       Date:  2008-11       Impact factor: 0.975

5.  Synthesis, characterization, and analgesic activity of novel schiff base of isatin derivatives.

Authors:  Rajaram Prakash Chinnasamy; Raja Sundararajan; Saravanan Govindaraj
Journal:  J Adv Pharm Technol Res       Date:  2010-07

Review 6.  Isatin derivatives as broad-spectrum antiviral agents: the current landscape.

Authors:  Tilal Elsaman; Malik Suliman Mohamed; Eyman Mohamed Eltayib; Hatem A Abdel-Aziz; Abualgasim Elgaili Abdalla; Muhammad Usman Munir; Magdi Awadalla Mohamed
Journal:  Med Chem Res       Date:  2022-01-13       Impact factor: 2.351

7.  Design, Synthesis of New 1,2,4-Triazole/1,3,4-Thiadiazole with Spiroindoline, Imidazo[4,5-b]quinoxaline and Thieno[2,3-d]pyrimidine from Isatin Derivatives as Anticancer Agents.

Authors:  Ameen Ali Abu-Hashem; Sami A Al-Hussain
Journal:  Molecules       Date:  2022-01-27       Impact factor: 4.411

8.  N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo.

Authors:  Liba Sebastian; Anita Desai; Madhusudana N Shampur; Yogeeswari Perumal; D Sriram; Ravi Vasanthapuram
Journal:  Virol J       Date:  2008-05-22       Impact factor: 4.099

9.  Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-N-substituted-hydrazinecarbothioamides.

Authors:  Subhas S Karki; Amol A Kulkarni; Sujeet Kumar; Suresh Kumar Veliyath; Erik De Clercq; Jan Balzarini
Journal:  Med Chem Res       Date:  2012-08-26       Impact factor: 1.965
  9 in total

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