Literature DB >> 10223957

Genetic characterization of resistance to extended-spectrum beta-lactams in Klebsiella oxytoca isolates recovered from patients with septicemia at hospitals in the Stockholm area.

S W Wu1, K Dornbusch, G Kronvall.   

Abstract

Two beta-lactamase gene regions were characterized by DNA sequencing in eight clinical isolates of Klebsiella oxytoca. The blaOXY-2a region encoded a beta-lactamase nearly identical to OXY-2 (one amino acid residue substituted) and conferred aztreonam and cefuroxime resistance on the K. oxytoca isolates. Overproduction of OXY-2a was caused by a G-to-A substitution of the fifth nucleotide in the -10 consensus sequence of blaOXY-2a. The blaOXY-1a was identified in a susceptible strain, and the OXY-1a enzyme differed from OXY-1 by two amino acid residues.

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Year:  1999        PMID： 10223957      PMCID： PMC89264     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

1.  A standard numbering scheme for the class A beta-lactamases.

Authors:  R P Ambler; A F Coulson; J M Frère; J M Ghuysen; B Joris; M Forsman; R C Levesque; G Tiraby; S G Waley
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

2.  Multiplicity of TEM-derived beta-lactamases from Klebsiella pneumoniae strains isolated at the same hospital and relationships between the responsible plasmids.

Authors:  C M Chanal; D L Sirot; A Petit; R Labia; A Morand; J L Sirot; R A Cluzel
Journal:  Antimicrob Agents Chemother       Date:  1989-11       Impact factor: 5.191

3.  [Multifactorial analysis of the phenotypes for beta-lactams of 1044 Escherichia coli strains].

Authors:  H Chardon; T Fosse; R Labia; M H Nicolas; C Poyart-Salmeron; J Sirot; D Sirot; M Veron
Journal:  Pathol Biol (Paris)       Date:  1993-04

4.  Incidence of multi-resistant gram-negative isolates in eight Dutch hospitals. The 1990 Dutch Surveillance Study.

Authors:  R J Buirma; A M Horrevorts; J H Wagenvoort
Journal:  Scand J Infect Dis Suppl       Date:  1991

5.  Clinical implications of multi-drug resistance in the intensive care unit.

Authors:  D R Snydman
Journal:  Scand J Infect Dis Suppl       Date:  1991

6.  Extended spectrum beta-lactamase from Klebsiella oxytoca, not belonging to the TEM or SHV family.

Authors:  S W Wu; K Dornbusch; M Norgren; G Kronvall
Journal:  J Antimicrob Chemother       Date:  1992-07       Impact factor: 5.790

7.  A survey of beta-lactamases from 618 isolates of Klebsiella spp.

Authors:  R Reig; C Roy; M Hermida; D Teruel; A Coira
Journal:  J Antimicrob Chemother       Date:  1993-01       Impact factor: 5.790

8.  Klebsiella oxytoca: resistance to aztreonam by overproduction of the chromosomally encoded beta-lactamase.

Authors:  B Fournier; G Arlet; P H Lagrange; A Philippon
Journal:  FEMS Microbiol Lett       Date:  1994-02-01       Impact factor: 2.742

9.  Resistance to cefotaxime and seven other beta-lactams in members of the family Enterobacteriaceae: a 3-year survey in France.

Authors:  D L Sirot; F W Goldstein; C J Soussy; A L Courtieu; M O Husson; J Lemozy; M Meyran; C Morel; R Perez; C Quentin-Noury
Journal:  Antimicrob Agents Chemother       Date:  1992-08       Impact factor: 5.191

10.  Characterization of Klebsiella oxytoca septicaemia isolates resistant to aztreonam and cefuroxime.

Authors:  S W Wu; K Dornbusch; E Göransson; U Ransjö; G Kronvall
Journal:  J Antimicrob Chemother       Date:  1991-09       Impact factor: 5.790
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  6 in total

1.  Six groups of the OXY beta-Lactamase evolved over millions of years in Klebsiella oxytoca.

Authors:  Cindy Fevre; Mehdi Jbel; Virginie Passet; François-Xavier Weill; Patrick A D Grimont; Sylvain Brisse
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

2.  Characterization and nucleotide sequence of a Klebsiella oxytoca cryptic plasmid encoding a CMY-type beta-lactamase: confirmation that the plasmid-mediated cephamycinase originated from the Citrobacter freundii AmpC beta-lactamase.

Authors:  S W Wu; K Dornbusch; G Kronvall; M Norgren
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191

3.  Biochemical-genetic analysis and distribution of DES-1, an Ambler class A extended-spectrum beta-lactamase from Desulfovibrio desulfuricans.

Authors:  Anne-Sophie Morin; Laurent Poirel; Francine Mory; Roger Labia; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2002-10       Impact factor: 5.191

4.  New Klebsiella oxytoca beta-lactamase genes bla(OXY-3) and bla(OXY-4) and a third genetic group of K oxytoca based on bla(OXY-3).

Authors:  Sophie A Granier; Véronique Leflon-Guibout; Fred W Goldstein; Marie-Hélène Nicolas-Chanoine
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191

5.  Population structure of multidrug resistant Klebsiella oxytoca within hospitals across the UK and Ireland identifies sharing of virulence and resistance genes with K. pneumoniae.

Authors:  Danesh Moradigaravand; Veronique Martin; Sharon J Peacock; Julian Parkhill
Journal:  Genome Biol Evol       Date:  2017-02-08       Impact factor: 3.416

6.  Characterization of Piperacillin/Tazobactam-Resistant Klebsiella oxytoca Recovered from a Nosocomial Outbreak.

Authors:  Ai Fujita; Kouji Kimura; Satoru Yokoyama; Wanchun Jin; Jun-Ichi Wachino; Keiko Yamada; Hiroyuki Suematsu; Yuka Yamagishi; Hiroshige Mikamo; Yoshichika Arakawa
Journal:  PLoS One       Date:  2015-11-05       Impact factor: 3.240
  6 in total

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