Literature DB >> 10221524

Aml1/ETO and Pml/RARA rearrangements in a case of AML-M2 acute myeloblastic leukemia with t(15;17).

M Varella-Garcia1, F Brizard, J Roche, G Flandrin, H Drabkin, A Brizard.   

Abstract

We report a case of acute myeloid leukemia FAB-type 2 with a translocation t(15;17)(q22;q12) On the basis of the cytological findings, a translocation t(8;21)(q22;q22) was suspected. FISH analyses using specific probes for t(15;17) and t(8;21) detected both PML/RARalpha and AML1/ETO rearrangements in a few percentage of cells. This case demonstrates the complexities that may occur between cytology and cytogenetic findings and the usefulness of FISH methods to detect an AML1/ETO rearrangement only suspected by cytological examination of bone marrow smears.

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Year:  1999        PMID： 10221524     DOI： 10.3109/10428199909058444

Source DB:  PubMed          Journal:  Leuk Lymphoma        ISSN： 1026-8022


  3 in total

1.  Early Detection of t(8;21) Chromosomal Translocations During Treatment of PML-RARA Positive Acute Promyelocytic Leukemia: A Case Study.

Authors:  Walter Kleine Neto; Mariana Serpa; Sabri Saeed Sanabani; Patricia Torres Bueno; Elvira Deolinda Rodrigues Pereira Velloso; Pedro Enrique Dorlhiac-Llacer; Israel Bendit
Journal:  Clin Med Insights Oncol       Date:  2010-12-20

2.  Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature.

Authors:  Burak Uz; Eylem Eliaçık; Ayse Işık; Salih Aksu; Yahya Büyükaşık; Ibrahim C Haznedaroğlu; Hakan Göker; Nilgün Sayınalp; Osman İ Ozcebe
Journal:  Turk J Haematol       Date:  2013-12-05       Impact factor: 1.831

3.  Early mortality in acute promyelocytic leukemia: Potential predictors.

Authors:  Can Chen; Xilian Huang; Kaile Wang; Kuang Chen; Danquan Gao; Shenxian Qian
Journal:  Oncol Lett       Date:  2018-01-24       Impact factor: 2.967
  3 in total

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