Influence of prostaglandins upon adenosine release and of adenosine upon prostaglandin release in the isolated rabbit heart.

Prostaglandin (PG) E1 with its high effect of coronary dilation causes a distinct increase in the adenosine release from the isolated rabbit heart (Langendorff technique). Compared to this, an equal dose of PGF2alpha increases the release of adenosine only to a small extent. Conversely, application of adenosine results in a considerable release of PG-like substances from the rabbit heart in vitro. The present investigations support the hypothesis that, apart from adenosine, PG's too, are involved in coronary regulation as modulators.