| Literature DB >> 10220282 |
I S Lee1, K Y Jung, S R Oh, S H Park, K S Ahn, H K Lee.
Abstract
We studied the structure-activity relationships of lignans from Schisandra chinensis and their derivatives as platelet activating factor (PAF) antagonists. Strong activity was shown in lignans without an ester group at C-6, a hydroxyl group at C-7 or a methylene dioxy moiety and with an R-biphenyl configuration. 6(7)-Dehydroschisandrol A, a derivative of schisandrol A, showed the highest activity (IC50, 2.1x10(-6) M) in this study.Entities:
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Year: 1999 PMID： 10220282 DOI： 10.1248/bpb.22.265
Source DB: PubMed Journal: Biol Pharm Bull ISSN： 0918-6158 Impact factor: 2.233