Literature DB >> 10220139

WRN mutations in Werner syndrome.

M J Moser1, J Oshima, R J Monnat.   

Abstract

Werner syndrome (WS) is one of a group of human genetic diseases that have recently been linked to deficits in cellular helicase function. We review the spectrum of WS-associated WRN mutations, the organization and potential functions of the WRN protein, and potential mechanistic links between the loss of WRN function and pathogenesis of the WS clinical and cellular phenotypes.

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Year:  1999        PMID： 10220139     DOI： 10.1002/(SICI)1098-1004(1999)13:4<271::AID-HUMU2>3.0.CO;2-Q

Source DB:  PubMed          Journal:  Hum Mutat        ISSN： 1059-7794            Impact factor:   4.878


  19 in total

1.  Mutations in the WRN gene in mice accelerate mortality in a p53-null background.

Authors:  D B Lombard; C Beard; B Johnson; R A Marciniak; J Dausman; R Bronson; J E Buhlmann; R Lipman; R Curry; A Sharpe; R Jaenisch; L Guarente
Journal:  Mol Cell Biol       Date:  2000-05       Impact factor: 4.272

2.  Ku complex interacts with and stimulates the Werner protein.

Authors:  M P Cooper; A Machwe; D K Orren; R M Brosh; D Ramsden; V A Bohr
Journal:  Genes Dev       Date:  2000-04-15       Impact factor: 11.361

3.  Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae.

Authors:  Kyungjae Myung; Richard D Kolodner
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-26       Impact factor: 11.205

4.  Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.

Authors:  L Wang; C E Ogburn; C B Ware; W C Ladiges; H Youssoufian; G M Martin; J Oshima
Journal:  Genetics       Date:  2000-01       Impact factor: 4.562

5.  Human RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases.

Authors:  Wenqing Fu; Alessio Ligabue; Kai J Rogers; Joshua M Akey; Raymond J Monnat
Journal:  Hum Mutat       Date:  2016-12-09       Impact factor: 4.878

6.  Loss of Werner syndrome protein function promotes aberrant mitotic recombination.

Authors:  P R Prince; M J Emond; R J Monnat
Journal:  Genes Dev       Date:  2001-04-15       Impact factor: 11.361

7.  Mechanism of Werner DNA helicase: POT1 and RPA stimulates WRN to unwind beyond gaps in the translocating strand.

Authors:  Byungchan Ahn; Jae Wan Lee; Hana Jung; Gad Beck; Vilhelm A Bohr
Journal:  PLoS One       Date:  2009-03-05       Impact factor: 3.240

8.  Arabidopsis RecQsim, a plant-specific member of the RecQ helicase family, can suppress the MMS hypersensitivity of the yeast sgs1 mutant.

Authors:  Mohammad B Bagherieh-Najjar; Onno M H de Vries; Johan T M Kroon; Emma L Wright; Kieran M Elborough; Jacques Hille; Paul P Dijkwel
Journal:  Plant Mol Biol       Date:  2003-05       Impact factor: 4.076

9.  Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.

Authors:  Kiranjit K Dhillon; Julia M Sidorova; Tina M Albertson; Judith B Anderson; Warren C Ladiges; Peter S Rabinovitch; Bradley D Preston; Raymond J Monnat
Journal:  DNA Repair (Amst)       Date:  2009-11-05

Review 10.  From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.

Authors:  L S Cox; R G A Faragher
Journal:  Cell Mol Life Sci       Date:  2007-10       Impact factor: 9.261
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