Literature DB >> 10220047

Down-regulation of steroidogenic acute regulatory (StAR) protein in rat Leydig cells: implications for regulation of testosterone production during aging.

S Leers-Sucheta1, D M Stocco, S Azhar.   

Abstract

Aging in rats is associated with reduced synthesis of steroid hormones. In the present study, response to gonadotropin and Bt2cAMP in vitro was significantly reduced in Leydig cells isolated from old versus young rats. StAR protein levels were similarly decreased in interstitial cells prepared from the testes of old rats.

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Year:  1999        PMID： 10220047     DOI： 10.1016/s0047-6374(98)00149-3

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  11 in total

1.  Effects of apigenin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse Leydig cells.

Authors:  Wei Li; Akhilesh K Pandey; Xiangling Yin; Jau-Jiin Chen; Douglas M Stocco; Paula Grammas; Xingjia Wang
Journal:  J Nutr Biochem       Date:  2011-03       Impact factor: 6.048

2.  Knockout of the transcription factor Nrf2: Effects on testosterone production by aging mouse Leydig cells.

Authors:  Haolin Chen; Shiying Jin; Jingjing Guo; Ponvijay Kombairaju; Shyam Biswal; Barry R Zirkin
Journal:  Mol Cell Endocrinol       Date:  2015-03-25       Impact factor: 4.102

Review 3.  A brief history of the search for the protein(s) involved in the acute regulation of steroidogenesis.

Authors:  Douglas M Stocco; Amy H Zhao; Lan N Tu; Kanako Morohaku; Vimal Selvaraj
Journal:  Mol Cell Endocrinol       Date:  2016-07-30       Impact factor: 4.102

4.  Autophagic deficiency is related to steroidogenic decline in aged rat Leydig cells.

Authors:  Wei-Ren Li; Liang Chen; Zhi-Jie Chang; Hua Xin; Tao Liu; Yan-Quan Zhang; Guang-Yong Li; Feng Zhou; Yan-Qing Gong; Zhe-Zhu Gao; Zhong-Cheng Xin
Journal:  Asian J Androl       Date:  2011-08-08       Impact factor: 3.285

5.  p38 MAPK regulates steroidogenesis through transcriptional repression of STAR gene.

Authors:  Syed Kashif Zaidi; Wen-Jun Shen; Stefanie Bittner; Alex Bittner; Mark P McLean; Jiahuai Han; Roger J Davis; Fredric B Kraemer; Salman Azhar
Journal:  J Mol Endocrinol       Date:  2014-04-29       Impact factor: 5.098

6.  Inhibition of testosterone synthesis induced by oral TiO2 NPs is associated with ROS-MAPK(ERK1/2)-StAR signaling pathway in SD rat.

Authors:  Shanji Liu; Yizhou Tang; Bolu Chen; Yu Zhao; Zoraida P Aguilar; Xueying Tao; Hengyi Xu
Journal:  Toxicol Res (Camb)       Date:  2021-08-09       Impact factor: 2.680

Review 7.  Leydig cells: From stem cells to aging.

Authors:  Haolin Chen; Ren-Shan Ge; Barry R Zirkin
Journal:  Mol Cell Endocrinol       Date:  2009-02-07       Impact factor: 4.102

8.  The role of specific mitogen-activated protein kinase signaling cascades in the regulation of steroidogenesis.

Authors:  Pulak R Manna; Douglas M Stocco
Journal:  J Signal Transduct       Date:  2011-01-05

9.  Sirt1 and Nrf2: regulation of Leydig cell oxidant/antioxidant intracellular environment and steroid formation†.

Authors:  Jin-Yong Chung; Haolin Chen; Barry Zirkin
Journal:  Biol Reprod       Date:  2021-11-15       Impact factor: 4.161

Review 10.  Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism.

Authors:  Luc J Martin; Mohamed Touaibia
Journal:  Antioxidants (Basel)       Date:  2020-03-13
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