| Literature DB >> 10219080 |
Y Z Liu1, L M Boxer, D S Latchman.
Abstract
The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from -1472 to -1414. This activation requires the Rap-1 G protein and the MEK-1 and p42/p44 MAPK enzymes but is independent of other NGF-activated signalling pathways involving protein kinase A or protein kinase C.Entities:
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Year: 1999 PMID： 10219080 PMCID： PMC148427 DOI： 10.1093/nar/27.10.2086
Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971