G Cserni1. 1. Department of Pathology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary. cserni@freemail.c3.hu
Abstract
BACKGROUND AND OBJECTIVES: THE fact that invasive lobular carcinoma (ILC) is often multicentric has led to mastectomies being regularly performed for this disease in some settings. Reproducibility of the histological typing of breast cancer was investigated. METHODS: Fifty slides from breast cancers were assessed individually by 10 pathologists from different institutions, whose findings were compared. RESULTS: The extent of matching of the reported histological types between the various pairs of pathologists ranged between 28 and 88%. Agreement was better for pathologists with special experience in breast pathology. The kappa values for the exact histological type, for pure ILC and for the presence of an ILC component, were 0.23, 0.31, and 0.32, respectively (0.64, 0.43, and 0.46 for pathologists experienced in breast pathology). CONCLUSIONS: The study demonstrates that there are equivocally interpreted tumors and the presence of ILC in the histological report should not serve as the sole determinant for the performance of mastectomy.
BACKGROUND AND OBJECTIVES: THE fact that invasive lobular carcinoma (ILC) is often multicentric has led to mastectomies being regularly performed for this disease in some settings. Reproducibility of the histological typing of breast cancer was investigated. METHODS: Fifty slides from breast cancers were assessed individually by 10 pathologists from different institutions, whose findings were compared. RESULTS: The extent of matching of the reported histological types between the various pairs of pathologists ranged between 28 and 88%. Agreement was better for pathologists with special experience in breast pathology. The kappa values for the exact histological type, for pure ILC and for the presence of an ILC component, were 0.23, 0.31, and 0.32, respectively (0.64, 0.43, and 0.46 for pathologists experienced in breast pathology). CONCLUSIONS: The study demonstrates that there are equivocally interpreted tumors and the presence of ILC in the histological report should not serve as the sole determinant for the performance of mastectomy.
Authors: Matthias Christgen; Leonie Donata Kandt; Wiebke Antonopoulos; Stephan Bartels; Mieke R Van Bockstal; Martin Bredt; Maria Jose Brito; Henriette Christgen; Cecile Colpaert; Bálint Cserni; Gábor Cserni; Maximilian E Daemmrich; Raihanatou Danebrock; Franceska Dedeurwaerdere; Carolien Hm van Deurzen; Ramona Erber; Christine Fathke; Henning Feist; Maryse Fiche; Claudia Aura Gonzalez; Natalie D Ter Hoeve; Loes Kooreman; Till Krech; Glen Kristiansen; Janina Kulka; Florian Laenger; Marcel Lafos; Ulrich Lehmann; Maria Dolores Martin-Martinez; Sophie Mueller; Enrico Pelz; Mieke Raap; Alberto Ravarino; Tanja Reineke-Plaass; Nora Schaumann; Anne-Marie Schelfhout; Maxim De Schepper; Jerome Schlue; Koen Van de Vijver; Wim Waelput; Axel Wellmann; Monika Graeser; Oleg Gluz; Sherko Kuemmel; Ulrike Nitz; Nadia Harbeck; Christine Desmedt; Giuseppe Floris; Patrick Wb Derksen; Paul J van Diest; Anne Vincent-Salomon; Hans Kreipe Journal: J Pathol Clin Res Date: 2021-12-10