Literature DB >> 10218589

Modulation of alpha-tropomyosin expression by alpha-tocopherol in rat vascular smooth muscle cells.

E Aratri1, S E Spycher, I Breyer, A Azzi.   

Abstract

The effect of alpha-tocopherol (vitamin E) on gene expression in rat vascular smooth muscle cells was studied by the differential display technique. One gene out of about 1000 genes analyzed, identified as alpha-tropomyosin, showed an increased transcription level caused by alpha-tocopherol treatment. Northern and Western blot analysis revealed a time-dependent transient up-regulation of the amount of mRNA (peak between 2 and 3 h) and protein (peak at 5 h) in alpha-tocopherol-treated cells. No effect was observed in cells treated with beta-tocopherol.

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Year:  1999        PMID： 10218589     DOI： 10.1016/s0014-5793(99)00277-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  The DFT local reactivity descriptors of α-tocopherol.

Authors:  Ivana Fabijanić; Cvijeta Jakobušić Brala; Viktor Pilepić
Journal:  J Mol Model       Date:  2015-03-28       Impact factor: 1.810

Review 2.  Vitamin E: action, metabolism and perspectives.

Authors:  E Herrera; C Barbas
Journal:  J Physiol Biochem       Date:  2001-03       Impact factor: 4.158

3.  Alpha-tocopherol ameliorates oxidative renal insult associated with spinal cord reperfusion injury.

Authors:  Mohamed D Morsy; Salah O Bashir
Journal:  J Physiol Biochem       Date:  2013-01-24       Impact factor: 4.158

4.  Novel transcriptional activities of vitamin E: inhibition of cholesterol biosynthesis.

Authors:  Scott Valastyan; Varsha Thakur; Amy Johnson; Karan Kumar; Danny Manor
Journal:  Biochemistry       Date:  2007-12-21       Impact factor: 3.162

5.  alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice.

Authors:  Sang-Kyu Park; Grier P Page; Kyoungmi Kim; David B Allison; Mohsen Meydani; Richard Weindruch; Tomas A Prolla
Journal:  J Nutr       Date:  2008-06       Impact factor: 4.798

6.  Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitro.

Authors:  Stéphane Pédeboscq; Christophe Rey; Muriel Petit; Catherine Harpey; Francesca De Giorgi; François Ichas; Lydia Lartigue
Journal:  PLoS One       Date:  2012-05-08       Impact factor: 3.240

Review 7.  So many options but one choice: the human body prefers alpha-tocopherol. A matter of stereochemistry.

Authors:  B Manolescu; V Atanasiu; C Cercasov; I Stoian; E Oprea; C Buşu
Journal:  J Med Life       Date:  2008 Oct-Dec
  7 in total

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