Literature DB >> 10218487

A novel inhibitor protein for Bombyx cysteine proteinase is homologous to propeptide regions of cysteine proteinases.

Y Yamamoto1, S Watabe, T Kageyama, S Y Takahashi.   

Abstract

A cDNA clone for an inhibitor of Bombyx cysteine proteinase was isolated and sequenced. Active inhibitor proteins were expressed in Escherichia coli using the cDNA. The open reading frame of the cDNA encodes a 105 residues protein with 19 residues of a signal sequence. The inhibitor has amino acid sequences homologous to several cysteine proteinases, but only to their propeptide sequences. The results suggest that some cysteine proteinase proregions may have evolved as autonomous modules and become inhibitor proteins for cysteine proteinases.

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Year:  1999        PMID： 10218487     DOI： 10.1016/s0014-5793(99)00382-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

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Authors:  Daniel J Rigden; Vladimir V Mosolov; Michael Y Galperin
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3.  Crystal structure of Bombyx mori arylphorins reveals a 3:3 heterohexamer with multiple papain cleavage sites.

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Journal:  Protein Sci       Date:  2014-04-02       Impact factor: 6.725

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Authors:  Yoriko Sawano; Ken-ichi Hatano; Takuya Miyakawa; Masaru Tanokura
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8.  Studies of inhibitory mechanisms of propeptide-like cysteine protease inhibitors.

Authors:  Bui T T Nga; Yuki Takeshita; Misa Yamamoto; Yoshimi Yamamoto
Journal:  Enzyme Res       Date:  2014-06-19

9.  Bioavailability of orally administered rhGM-CSF: a single-dose, randomized, open-label, two-period crossover trial.

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Journal:  PLoS One       Date:  2009-05-12       Impact factor: 3.240

10.  Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster.

Authors:  Tien-Sheng Tseng; Chao-Sheng Cheng; Shang-Te Danny Hsu; Min-Fang Shih; Pei-Lin He; Ping-Chiang Lyu
Journal:  PLoS One       Date:  2013-01-21       Impact factor: 3.240
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