AIMS: The TNM system is the main parameter in treatment planning and the prediction of survival in oral cancer. Here, we investigate the role of tumour thickness as a predictor of locoregional failure and survival in node-negative patients. METHODS: We studied 176 node-negative and early stage gingivo-buccal squamous cell carcinoma patients retrospectively. Clinico-pathological factors investigated for tumour failure prediction were: T stage; tumour differentiation; tumour thickness; and treatment. Tumour thickness was measured using an ocular micrometer. RESULTS: Locoregional tumour failure was found in 34% of cases (60 of 176). Tumour differentiation was found not to be statistically significant in predicting tumour failure. The covariates predicting tumour failure were T stage (P<0.05); type of surgical treatment (P<0.05); and tumour thickness (P<0.001). The mean tumour thickness found was 4 mm. Tumours 4 mm in thickness behaved similarly in all three stages and those >4 mm had a higher rate of lymph-node metastasis. No distant metastasis was found in this series. CONCLUSION: Tumour thickness was found to be an accurate predictor of locoregional failure in early stage cancer of the buccal mucosa.
AIMS: The TNM system is the main parameter in treatment planning and the prediction of survival in oral cancer. Here, we investigate the role of tumour thickness as a predictor of locoregional failure and survival in node-negative patients. METHODS: We studied 176 node-negative and early stage gingivo-buccal squamous cell carcinomapatients retrospectively. Clinico-pathological factors investigated for tumour failure prediction were: T stage; tumour differentiation; tumour thickness; and treatment. Tumour thickness was measured using an ocular micrometer. RESULTS: Locoregional tumour failure was found in 34% of cases (60 of 176). Tumour differentiation was found not to be statistically significant in predicting tumour failure. The covariates predicting tumour failure were T stage (P<0.05); type of surgical treatment (P<0.05); and tumour thickness (P<0.001). The mean tumour thickness found was 4 mm. Tumours 4 mm in thickness behaved similarly in all three stages and those >4 mm had a higher rate of lymph-node metastasis. No distant metastasis was found in this series. CONCLUSION:Tumour thickness was found to be an accurate predictor of locoregional failure in early stage cancer of the buccal mucosa.
Authors: Ardalan Ebrahimi; Ziv Gil; Moran Amit; Tzu-Chen Yen; Chun-Ta Liao; Pankaj Chaturvedi; Jai Prakash Agarwal; Luiz P Kowalski; Hugo F Köhler; Matthias Kreppel; Claudio R Cernea; Jason Brandao; Gideon Bachar; Andrea Bolzoni Villaret; Dan M Fliss; Eran Fridman; Kevin Thomas Robbins; Jatin P Shah; Snehal G Patel; Jonathan R Clark Journal: Head Neck Date: 2019-02-24 Impact factor: 3.147
Authors: Rohan R Walvekar; Devendra A Chaukar; Mandar S Deshpande; Prathamesh S Pai; Pankaj Chaturvedi; Anagha C Kakade; Anil K D'Cruz Journal: Eur Arch Otorhinolaryngol Date: 2010-01-12 Impact factor: 2.503
Authors: Pawadee Lohavanichbutr; John Houck; David R Doody; Pei Wang; Eduardo Mendez; Neal Futran; Melissa P Upton; F Christopher Holsinger; Stephen M Schwartz; Chu Chen Journal: PLoS One Date: 2012-09-28 Impact factor: 3.240
Authors: Linda Boldrup; Xiaolian Gu; Philip J Coates; Lena Norberg-Spaak; Robin Fahraeus; Göran Laurell; Torben Wilms; Karin Nylander Journal: Oncotarget Date: 2017-03-21
Authors: R K De Silva; B S M S Siriwardena; A Samaranayaka; W A M U L Abeyasinghe; W M Tilakaratne Journal: PLoS One Date: 2018-08-09 Impact factor: 3.240