OBJECTIVE: To report a rare case of scrotal granular cell tumor. METHODS: A 19-year-old man presented with a nodule on the scrotum, 2 cm in diameter. It had been present for months and was covered with ulcerated epidermis. The tumor was resected. RESULTS: The histological study disclosed a neoplasm composed of polygonal cells with cytoplasmic granules and pseudoepitheliomatous hyperplasia of the overlying skin. Immunohistochemically, the cells showed a strong positivity for S100 protein and vimentin. The proliferation index (ki 67) was low in its cells, but high in the overlying hyperplasic epidermal cells. CONCLUSIONS: To our knowledge, this is the second case of scrotal granular cell tumor reported. The case described herein has the unique feature of severe overlying pseudoepitheliomatous hyperplasia. S100 positivity supports a neurogenic differentiation.
OBJECTIVE: To report a rare case of scrotal granular cell tumor. METHODS: A 19-year-old man presented with a nodule on the scrotum, 2 cm in diameter. It had been present for months and was covered with ulcerated epidermis. The tumor was resected. RESULTS: The histological study disclosed a neoplasm composed of polygonal cells with cytoplasmic granules and pseudoepitheliomatous hyperplasia of the overlying skin. Immunohistochemically, the cells showed a strong positivity for S100 protein and vimentin. The proliferation index (ki 67) was low in its cells, but high in the overlying hyperplasic epidermal cells. CONCLUSIONS: To our knowledge, this is the second case of scrotal granular cell tumor reported. The case described herein has the unique feature of severe overlying pseudoepitheliomatous hyperplasia. S100 positivity supports a neurogenic differentiation.