Literature DB >> 10217732

Pregnane glycoside multidrug-resistance modulators from Cynanchum wilfordii.

B Y Hwang1, S E Kim, Y H Kim, H S Kim, Y S Hong, J S Ro, K S Lee, J J Lee.   

Abstract

The methanol-soluble extracts of the roots of Cynanchum wilfordii showed a significant multidrug-resistance-reversing activity, and four known pregnane glycosides were isolated by bioassay-directed fractionation and separation. Their structures were identified as gagaminin 3-O-beta-D-cymaropyranosyl-(1-->4)-beta-D-oleandropyranosyl- (1-->4)-b eta-D-cymaropyranosyl-(1-->4)-beta-D-cymaropyranoside (1), wilfoside K1N (2), wilfoside C1N (3), and cynauricuoside A (4). In particular, compound 1, at a concentration level of 1 microM, was found to completely reverse the multidrug-resistance of KB-V1 and MCF7/ADR cells to adriamycin, vinblastine, and colchicine.

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Year:  1999        PMID： 10217732     DOI： 10.1021/np980479x

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

1.  Improved endothelial dysfunction by Cynanchum wilfordii in apolipoprotein E(-/-) mice fed a high fat/cholesterol diet.

Authors:  Deok Ho Choi; Yun Jung Lee; Hyun Cheol Oh; Ying Lan Cui; Jin Sook Kim; Dae Gill Kang; Ho Sub Lee
Journal:  J Med Food       Date:  2011-11-14       Impact factor: 2.786

2.  An ethanol root extract of Cynanchum wilfordii containing acetophenones suppresses the expression of VCAM-1 and ICAM-1 in TNF-α-stimulated human aortic smooth muscle cells through the NF-κB pathway.

Authors:  Hyun Jung Koo; Eun-Hwa Sohn; Suhkneung Pyo; Han Goo Woo; Dae Won Park; Young-Min Ham; Seon-A Jang; Soo-Yeong Park; Se Chan Kang
Journal:  Int J Mol Med       Date:  2015-02-26       Impact factor: 4.101

3.  Cynanchum wilfordii Polysaccharides Suppress Dextran Sulfate Sodium-Induced Acute Colitis in Mice and the Production of Inflammatory Mediators from Macrophages.

Authors:  Chang-Won Cho; Sungeun Ahn; Tae-Gyu Lim; Hee-Do Hong; Young Kyoung Rhee; Deok-Chun Yang; Mi Jang
Journal:  Mediators Inflamm       Date:  2017-06-20       Impact factor: 4.711

4.  Preliminary Quality Evaluation and Characterization of Phenolic Constituents in Cynanchi Wilfordii Radix.

Authors:  Takashi Uchikura; Hiroaki Tanaka; Hidemi Sugiwaki; Morio Yoshimura; Naoko Sato-Masumoto; Takashi Tsujimoto; Nahoko Uchiyama; Takashi Hakamatsuka; Yoshiaki Amakura
Journal:  Molecules       Date:  2018-03-14       Impact factor: 4.411

5.  Cynandione A Alleviates Neuropathic Pain Through α7-nAChR-Dependent IL-10/β-Endorphin Signaling Complexes.

Authors:  Qiao-Qiao Han; Min Yin; Zi-Ying Wang; Hao Liu; Jun-Ping Ao; Yong-Xiang Wang
Journal:  Front Pharmacol       Date:  2021-01-27       Impact factor: 5.810

Review 6.  Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects.

Authors:  Lu Wang; Fujie Cai; Wei Zhao; Jinli Tian; Degang Kong; Xiaohui Sun; Qing Liu; Yueru Chen; Ying An; Fulin Wang; Xue Liu; Yi Wu; Honglei Zhou
Journal:  Molecules       Date:  2021-11-23       Impact factor: 4.411

7.  Immune-Enhancing Effects of a High Molecular Weight Fraction of Cynanchum wilfordii Hemsley in Macrophages and Immunosuppressed Mice.

Authors:  Mi Jang; Tae-Gyu Lim; Sungeun Ahn; Hee-Do Hong; Young Kyoung Rhee; Kyung-Tack Kim; Eunjung Lee; Jeong Hoon Lee; Yun Ji Lee; Chan Sik Jung; Dae Young Lee; Chang-Won Cho
Journal:  Nutrients       Date:  2016-09-27       Impact factor: 5.717

Review 8.  Ethnobotany, Phytochemistry and Pharmacological Effects of Plants in Genus Cynanchum Linn. (Asclepiadaceae).

Authors:  Lu Han; Xiuping Zhou; Mengmeng Yang; Li Zhou; Xinxin Deng; Shijie Wei; Wenping Wang; Zhizhong Wang; Xue Qiao; Changcai Bai
Journal:  Molecules       Date:  2018-05-16       Impact factor: 4.411
  8 in total

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