J S Adams1, C F Song, V Kantorovich. 1. Burns and Allen Research Institute and Cedars-Sinai Medical Center, University of California, Los Angeles, School of Medicine 90048, USA. adamsj@cshs.org
Abstract
BACKGROUND: Chronic hypercalciuria can contribute to osteoporosis, particularly in men. OBJECTIVE: To ascertain the effects of resolution of hypercalciuria on bone mineral density. DESIGN: Case series. SETTING: Referral service for metabolic bone disease in a tertiary-care teaching hospital. PATIENTS: Five male patients (42 to 66 years of age) with hypercalciuria and osteoporosis. INTERVENTION: Hydrochlorothiazide, 25 mg twice daily, for a mean (+/- SD) of 7.8 +/- 3.6 months. MEASUREMENTS: Fasting urinary calcium:creatinine ratio, serum calciotropic hormone levels, and bone mineral density before and after hydrochlorothiazide administration. RESULTS: Hydrochlorothiazide resolved hypercalciuria and increased bone mineral density at a rate of 8% and 3% per year at the spine and hip, respectively. CONCLUSIONS: Hydrochlorothiazide treatment in hypercalciuric and osteoporotic men was associated with a rapid rebound increase in bone mineral density.
BACKGROUND: Chronic hypercalciuria can contribute to osteoporosis, particularly in men. OBJECTIVE: To ascertain the effects of resolution of hypercalciuria on bone mineral density. DESIGN: Case series. SETTING: Referral service for metabolic bone disease in a tertiary-care teaching hospital. PATIENTS: Five male patients (42 to 66 years of age) with hypercalciuria and osteoporosis. INTERVENTION: Hydrochlorothiazide, 25 mg twice daily, for a mean (+/- SD) of 7.8 +/- 3.6 months. MEASUREMENTS: Fasting urinary calcium:creatinine ratio, serum calciotropic hormone levels, and bone mineral density before and after hydrochlorothiazide administration. RESULTS:Hydrochlorothiazide resolved hypercalciuria and increased bone mineral density at a rate of 8% and 3% per year at the spine and hip, respectively. CONCLUSIONS:Hydrochlorothiazide treatment in hypercalciuric and osteoporoticmen was associated with a rapid rebound increase in bone mineral density.
Authors: Nancy S Krieger; John R Asplin; Ignacio Granja; Felix M Ramos; Courtney Flotteron; Luojing Chen; Tong Tong Wu; Marc D Grynpas; David A Bushinsky Journal: J Am Soc Nephrol Date: 2019-05-17 Impact factor: 10.121
Authors: Hendrica Belge; Philippe Gailly; Beat Schwaller; Johannes Loffing; Huguette Debaix; Eva Riveira-Munoz; Renaud Beauwens; Jean-Pierre Devogelaer; Joost G Hoenderop; René J Bindels; Olivier Devuyst Journal: Proc Natl Acad Sci U S A Date: 2007-09-05 Impact factor: 11.205