Literature DB >> 10215022

The putative gene for the first enzyme of glutathione biosynthesis in Plasmodium berghei and Plasmodium falciparum.

C Birago1, T Pace, L Picci, E Pizzi, R Scotti, M Ponzi.   

Abstract

The putative gene for gamma-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione biosynthesis, has been characterized both in Plasmodium berghei and Plasmodium falciparum. Protein sequence comparison between these two species reveals large conserved regions sharing more than 80% similarity, separated by less conserved portions. When the comparison is extended to known gamma-glutamylcysteine synthetases from other eukaryotes, a number of high similarity blocks are observed which may help in identifying sequence essential for protein function.

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Year:  1999        PMID： 10215022     DOI： 10.1016/s0166-6851(98)00179-0

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  5 in total

1.  Interspecies conservation of gene order and intron-exon structure in a genomic locus of high gene density and complexity in Plasmodium.

Authors:  L H van Lin; T Pace; C J Janse; C Birago; J Ramesar; L Picci; M Ponzi; A P Waters
Journal:  Nucleic Acids Res       Date:  2001-05-15       Impact factor: 16.971

2.  Low-complexity regions in Plasmodium falciparum proteins.

Authors:  E Pizzi; C Frontali
Journal:  Genome Res       Date:  2001-02       Impact factor: 9.043

3.  Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito.

Authors:  Rebecca Pastrana-Mena; Rhoel R Dinglasan; Blandine Franke-Fayard; Joel Vega-Rodríguez; Mariela Fuentes-Caraballo; Abel Baerga-Ortiz; Isabelle Coppens; Marcelo Jacobs-Lorena; Chris J Janse; Adelfa E Serrano
Journal:  J Biol Chem       Date:  2010-06-23       Impact factor: 5.157

4.  Identification and bioinformatic characterization of a multidrug resistance associated protein (ABCC) gene in Plasmodium berghei.

Authors:  María González-Pons; Ada C Szeto; Ricardo González-Méndez; Adelfa E Serrano
Journal:  Malar J       Date:  2009-01-02       Impact factor: 2.979

5.  The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission.

Authors:  Joel Vega-Rodríguez; Blandine Franke-Fayard; Rhoel R Dinglasan; Chris J Janse; Rebecca Pastrana-Mena; Andrew P Waters; Isabelle Coppens; José F Rodríguez-Orengo; Prakash Srinivasan; Marcelo Jacobs-Lorena; Adelfa E Serrano
Journal:  PLoS Pathog       Date:  2009-02-20       Impact factor: 6.823
  5 in total

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