Literature DB >> 10214942

PPARgamma activators down-regulate the expression of PPARgamma in 3T3-L1 adipocytes.

H S Camp1, A L Whitton, S R Tafuri.   

Abstract

Transcriptional activation of PPARgamma by the anti-diabetic compound troglitazone enhances the rate of 3T3-L1 adipocyte differentiation. In this study, we examined the effects of troglitazone, a specific PPARgamma ligand, on the expression of PPARgamma during and after 3T3-L1 adipocyte differentiation. Troglitazone treatment caused a significant decrease in PPARgamma proteins and DNA binding activity. This reduction was associated with a similar decrease in transcription of PPARgamma mRNA. These data suggest that in 3T3-L1 cells, the expression of PPARgamma is auto-regulated.

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Year:  1999        PMID： 10214942     DOI： 10.1016/s0014-5793(99)00268-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

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Authors:  Philip Hallenborg; Claus Jørgensen; Rasmus K Petersen; Søren Feddersen; Pedro Araujo; Patrick Markt; Thierry Langer; Gerhard Furstenberger; Peter Krieg; Arjen Koppen; Eric Kalkhoven; Lise Madsen; Karsten Kristiansen
Journal:  Mol Cell Biol       Date:  2010-06-07       Impact factor: 4.272

2.  Novel method to differentiate 3T3 L1 cells in vitro to produce highly sensitive adipocytes for a GLUT4 mediated glucose uptake using fluorescent glucose analog.

Authors:  Divya Vishwanath; Harini Srinivasan; Manjunath S Patil; Sowmya Seetarama; Sachin Kumar Agrawal; M N Dixit; Kakali Dhar
Journal:  J Cell Commun Signal       Date:  2013-01-06       Impact factor: 5.782

3.  Proteomic analysis of rosiglitazone and guggulsterone treated 3T3-L1 preadipocytes.

Authors:  Pooja Pal; Jitendra K Kanaujiya; Savita Lochab; Shashi B Tripathi; Sabyasachi Sanyal; Gerhard Behre; Arun K Trivedi
Journal:  Mol Cell Biochem       Date:  2012-12-30       Impact factor: 3.396

4.  Acute genome-wide effects of rosiglitazone on PPARγ transcriptional networks in adipocytes.

Authors:  Anders Kristian Haakonsson; Maria Stahl Madsen; Ronni Nielsen; Albin Sandelin; Susanne Mandrup
Journal:  Mol Endocrinol       Date:  2013-07-24

5.  PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis.

Authors:  Delin Ren; Trevor N Collingwood; Edward J Rebar; Alan P Wolffe; Heidi S Camp
Journal:  Genes Dev       Date:  2002-01-01       Impact factor: 11.361

6.  Selective modulation of promoter recruitment and transcriptional activity of PPARgamma.

Authors:  Dorothy D Sears; Albert Hsiao; Jachelle M Ofrecio; Justin Chapman; Weimin He; Jerrold M Olefsky
Journal:  Biochem Biophys Res Commun       Date:  2007-10-18       Impact factor: 3.575

Review 7.  The Role of Lipid Sensing Nuclear Receptors (PPARs and LXR) and Metabolic Lipases in Obesity, Diabetes and NAFLD.

Authors:  Emmanuel D Dixon; Alexander D Nardo; Thierry Claudel; Michael Trauner
Journal:  Genes (Basel)       Date:  2021-04-26       Impact factor: 4.096

8.  The effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity.

Authors:  Parizad Taraghijou; Abdolrasoul Safaeiyan; Majid Mobasseri; Alireza Ostadrahimi
Journal:  J Res Med Sci       Date:  2012-10       Impact factor: 1.852

9.  Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.

Authors:  Francisco José Ortega; Marta Serrano; Sergio Rodriguez-Cuenca; José María Moreno-Navarrete; María Gómez-Serrano; Mònica Sabater; Jose Ignacio Rodriguez-Hermosa; Gemma Xifra; Wifredo Ricart; Belén Peral; Antonio Vidal-Puig; José Manuel Fernández-Real
Journal:  J Mol Med (Berl)       Date:  2014-09-25       Impact factor: 4.599

10.  Matrigel® enhances 3T3-L1 cell differentiation.

Authors:  Chitmandeep Josan; Sachin Kakar; Sandeep Raha
Journal:  Adipocyte       Date:  2021-12       Impact factor: 4.534
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