| Literature DB >> 10214763 |
M K Sharief1, A Green, J P Dick, J Gawler, E J Thompson.
Abstract
The authors report high intrathecal release of tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1beta in five patients with sporadic or new-variant Creutzfeldt-Jakob disease (CJD) without activation of the humoral or lymphocytic immune responses. Increased release of TNF-alpha and IL-1beta was also detected in some patients with progressive dementias. CJD is associated with a local cerebral host response that involves the release of proinflammatory cytokines.Entities:
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Year: 1999 PMID： 10214763 DOI： 10.1212/wnl.52.6.1289
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910