Literature DB >> 10214759

The evolution of neutralizing antibodies in multiple sclerosis patients treated with interferon beta-1b.

G P Rice1, B Paszner, J Oger, J Lesaux, D Paty, G Ebers.   

Abstract

The fate of the neutralizing antibody (NAB) in MS patients treated with interferons remains unclear. We conducted a follow-up survey of NAB titers in 59 long-term treated patients from the London and Vancouver cohorts of the pivotal trial of interferon alpha-1b. NAB were measured with the myxovirus protein A assay and an ELISA, at a mean follow-up that exceeded 8 years. NAB disappeared in the majority of patients.

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Year:  1999        PMID: 10214759     DOI: 10.1212/wnl.52.6.1277

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  19 in total

Review 1.  Interferon in relapsing-remitting multiple sclerosis.

Authors:  G P Rice; B Incorvaia; L Munari; G Ebers; C Polman; R D'Amico; G Filippini
Journal:  Cochrane Database Syst Rev       Date:  2001

Review 2.  Management of secondary-progressive multiple sclerosis.

Authors:  Gavin Giovannoni
Journal:  CNS Drugs       Date:  2004       Impact factor: 5.749

Review 3.  Is multiple sclerosis a disease that requires frequent beta interferon dosing?

Authors:  Luca Durelli
Journal:  J Neurol       Date:  2004-09       Impact factor: 4.849

4.  Neutralizing antibodies against interferon-Beta.

Authors:  Per Soelberg Sorensen
Journal:  Ther Adv Neurol Disord       Date:  2008-09       Impact factor: 6.570

5.  Predictive factors of neutralizing antibodies development in relapsing-remitting multiple sclerosis patients on interferon Beta-1b therapy.

Authors:  R Lanzillo; G Orefice; A Prinster; G Ventrella; R Liuzzi; V Scarano; C Florio; G Vacca; A Brunetti; B Alfano; V Brescia Morra; V Bonavita
Journal:  Neurol Sci       Date:  2011-02-10       Impact factor: 3.307

Review 6.  Long-term experience with interferon beta-1b (Betaferon)in multiple sclerosis.

Authors:  Barry G W Arnason
Journal:  J Neurol       Date:  2005-09       Impact factor: 4.849

7.  A sensitive radioimmunoprecipitation assay for assessing the clinical relevance of antibodies to IFN beta.

Authors:  N Lawrence; J Oger; T Aziz; J Palace; A Vincent
Journal:  J Neurol Neurosurg Psychiatry       Date:  2003-09       Impact factor: 10.154

Review 8.  Neutralizing antibodies to interferon-beta and other immunological treatments for multiple sclerosis: prevalence and impact on outcomes.

Authors:  Florian Deisenhammer
Journal:  CNS Drugs       Date:  2009       Impact factor: 5.749

9.  Review of interferon beta-1b in the treatment of early and relapsing multiple sclerosis.

Authors:  Damiano Paolicelli; Vita Direnzo; Maria Trojano
Journal:  Biologics       Date:  2009-07-13

10.  Early stage and long term treatment of multiple sclerosis with interferon-beta.

Authors:  Angela Applebee; Hillel Panitch
Journal:  Biologics       Date:  2009-07-13
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