Literature DB >> 10213686

Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen.

M E Ballestas1, P A Chatis, K M Kaye.   

Abstract

Primary effusion lymphoma (PEL) cells harbor Kaposi's sarcoma-associated herpesvirus (KSHV) episomes and express a KSHV-encoded latency-associated nuclear antigen (LANA). In PEL cells, LANA and KSHV DNA colocalized in dots in interphase nuclei and along mitotic chromosomes. In the absence of KSHV DNA, LANA was diffusely distributed in the nucleus or on mitotic chromosomes. In lymphoblasts, LANA was necessary and sufficient for the persistence of episomes containing a specific KSHV DNA fragment. Furthermore, LANA colocalized with the artificial KSHV DNA episomes in nuclei and along mitotic chromosomes. These results support a model in which LANA tethers KSHV DNA to chromosomes during mitosis to enable the efficient segregation of KSHV episomes to progeny cells.

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Year:  1999        PMID： 10213686     DOI： 10.1126/science.284.5414.641

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  352 in total

1.  Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays.

Authors:  R G Jenner; M M Albà; C Boshoff; P Kellam
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

2.  Internal ribosome entry site regulates translation of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein.

Authors:  W Low; M Harries; H Ye; M Q Du; C Boshoff; M Collins
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

Review 3.  Evolutionary aspects of oncogenic herpesviruses.

Authors:  J Nicholas
Journal:  Mol Pathol       Date:  2000-10

4.  Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies.

Authors:  D R Schwam; R L Luciano; S S Mahajan; L Wong; A C Wilson
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

5.  The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells.

Authors:  Jianhong Hu; Alexander C Garber; Rolf Renne
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

6.  Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes.

Authors:  Anita Krithivas; Masahiro Fujimuro; Magdalena Weidner; David B Young; S Diane Hayward
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

7.  The Herpesvirus Saimiri open reading frame 73 gene product interacts with the cellular protein p32.

Authors:  Kersten T Hall; Mathew S Giles; Michael A Calderwood; Delyth J Goodwin; David A Matthews; Adrian Whitehouse
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

8.  Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1.

Authors:  Hirohiko Shinohara; Masaya Fukushi; Masaya Higuchi; Masayasu Oie; Osamu Hoshi; Tatsuo Ushiki; Jun-Ichi Hayashi; Masahiro Fujii
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

9.  Spindle cell conversion by Kaposi's sarcoma-associated herpesvirus: formation of colonies and plaques with mixed lytic and latent gene expression in infected primary dermal microvascular endothelial cell cultures.

Authors:  D M Ciufo; J S Cannon; L J Poole; F Y Wu; P Murray; R F Ambinder; G S Hayward
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

10.  Functional dissection of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus involved in latent DNA replication and transcription of terminal repeats of the viral genome.

Authors:  Chunghun Lim; Hekwang Sohn; Daeyoup Lee; Yousang Gwack; Joonho Choe
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103
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