AIMS: To determine the prevalence of heart failure and symptomatic as well as asymptomatic left ventricular systolic dysfunction in the general population. METHODS AND RESULTS: In 5540 participants of the Rotterdam Study (age 68.9+/-8.7 years, 2251 men) aged 55-95 years, the presence of heart failure was determined by assessment of symptoms and signs (shortness of breath. ankle oedema and pulmonary crepitations) and use of heart failure medication. In 2267 subjects (age 65.7+/-7.4 years, 1028 men) fractional shortening was measured. The overall prevalence of heart failure was 3.9% (95% CI 3.0+/-4.7) and did not differ between men and women. The prevalence increased with age, with the exception of the highest age group in men. Fractional shortening was higher in women and did not decrease appreciably with age. The prevalence of left ventricular systolic dysfunction (fractional shortening <=25%) was approximately 2.5 times higher in men (5.5%, 95% CI 4.1-7.0) than in women (2.2%, 95% CI 1.4-3.2). Sixty percent of persons with left ventricular systolic dysfunction had no symptoms or signs of heart failure at all. CONCLUSIONS: The prevalence of heart failure is appreciable and does not differ between men and women. The majority of persons with left ventricular systolic dysfunction can be regarded as having asymptomatic left ventricular systolic dysfunction.
AIMS: To determine the prevalence of heart failure and symptomatic as well as asymptomatic left ventricular systolic dysfunction in the general population. METHODS AND RESULTS: In 5540 participants of the Rotterdam Study (age 68.9+/-8.7 years, 2251 men) aged 55-95 years, the presence of heart failure was determined by assessment of symptoms and signs (shortness of breath. ankle oedema and pulmonary crepitations) and use of heart failure medication. In 2267 subjects (age 65.7+/-7.4 years, 1028 men) fractional shortening was measured. The overall prevalence of heart failure was 3.9% (95% CI 3.0+/-4.7) and did not differ between men and women. The prevalence increased with age, with the exception of the highest age group in men. Fractional shortening was higher in women and did not decrease appreciably with age. The prevalence of left ventricular systolic dysfunction (fractional shortening <=25%) was approximately 2.5 times higher in men (5.5%, 95% CI 4.1-7.0) than in women (2.2%, 95% CI 1.4-3.2). Sixty percent of persons with left ventricular systolic dysfunction had no symptoms or signs of heart failure at all. CONCLUSIONS: The prevalence of heart failure is appreciable and does not differ between men and women. The majority of persons with left ventricular systolic dysfunction can be regarded as having asymptomatic left ventricular systolic dysfunction.
Authors: Stefan Walter; Johan Mackenbach; Zoltán Vokó; Stefan Lhachimi; M Arfan Ikram; André G Uitterlinden; Anne B Newman; Joanne M Murabito; Melissa E Garcia; Vilmundur Gudnason; Toshiko Tanaka; Gregory J Tranah; Henri Wallaschofski; Thomas Kocher; Lenore J Launer; Nora Franceschini; Maarten Schipper; Albert Hofman; Henning Tiemeier Journal: Am J Public Health Date: 2012-02-16 Impact factor: 9.308
Authors: L M Boerman; A J Berendsen; P van der Meer; J H Maduro; M Y Berger; G H de Bock Journal: Support Care Cancer Date: 2014-03-02 Impact factor: 3.603
Authors: Amil M Shah; Susan Cheng; Hicham Skali; Justina Wu; Judy R Mangion; Dalane Kitzman; Kunihiro Matsushita; Suma Konety; Kenneth R Butler; Ervin R Fox; Nakela Cook; Hanyu Ni; Josef Coresh; Thomas H Mosley; Gerardo Heiss; Aaron R Folsom; Scott D Solomon Journal: Circ Cardiovasc Imaging Date: 2013-11-08 Impact factor: 7.792