Literature DB >> 10213160

Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques.

H G Bernstein1, S Ansorge, P Riederer, M Reiser, L Frölich, B Bogerts.   

Abstract

The anatomical distribution of insulin-degrading enzyme (IDE) was studied in normal and Alzheimer's disease (AD) human brains. By use of a monospecific, polyclonal antiserum against the enzyme we identified IDE antigen in multiple cortical and subcortical neurons. Glia did not show IDE immunoreactivity. In AD brains immunostaining appeared stronger than in controls and appeared not only in neurons but also in senile plaques. In a probable case of Lewy body variant of AD Lewy bodies in neurons of the Nuc. basalis of Meynert were immunopositive for IDE. Our anatomical data suggest that the enzyme is associated with typical neuropathologic hallmarks of AD and its expression appears up-regulated in some brain areas.

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Year:  1999        PMID： 10213160     DOI： 10.1016/s0304-3940(99)00135-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  31 in total

1.  Ubiquitin is a novel substrate for human insulin-degrading enzyme.

Authors:  Luis A Ralat; Vasilios Kalas; Zhongzhou Zheng; Robert D Goldman; Tobin R Sosnick; Wei-Jen Tang
Journal:  J Mol Biol       Date:  2010-12-23       Impact factor: 5.469

2.  Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.

Authors:  K Vekrellis; Z Ye; W Q Qiu; D Walsh; D Hartley; V Chesneau; M R Rosner; D J Selkoe
Journal:  J Neurosci       Date:  2000-03-01       Impact factor: 6.167

3.  Functional relevance of a novel SlyX motif in non-conventional secretion of insulin-degrading enzyme.

Authors:  Konstantin Glebov; Sebastian Schütze; Jochen Walter
Journal:  J Biol Chem       Date:  2011-05-16       Impact factor: 5.157

4.  Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism.

Authors:  María C Leal; Ezequiel I Surace; María P Holgado; Carina C Ferrari; Rodolfo Tarelli; Fernando Pitossi; Thomas Wisniewski; Eduardo M Castaño; Laura Morelli
Journal:  Biochim Biophys Acta       Date:  2011-10-19

5.  17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention.

Authors:  Liqin Zhao; Jia Yao; Zisu Mao; Shuhua Chen; Yan Wang; Roberta Diaz Brinton
Journal:  Neurobiol Aging       Date:  2010-01-06       Impact factor: 4.673

6.  Zinc metalloproteinases and amyloid Beta-Peptide metabolism: the positive side of proteolysis in Alzheimer's disease.

Authors:  Mallory Gough; Catherine Parr-Sturgess; Edward Parkin
Journal:  Biochem Res Int       Date:  2010-09-30

Review 7.  Insulin resistance and Alzheimer's disease.

Authors:  Suzanne M de la Monte
Journal:  BMB Rep       Date:  2009-08-31       Impact factor: 4.778

Review 8.  Brain insulin dysregulation: implication for neurological and neuropsychiatric disorders.

Authors:  Rasoul Ghasemi; Leila Dargahi; Ali Haeri; Maryam Moosavi; Zahurin Mohamed; Abolhassan Ahmadiani
Journal:  Mol Neurobiol       Date:  2013-01-20       Impact factor: 5.590

9.  Brain regional correlation of amyloid-β with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-β accumulation.

Authors:  Mitsuru Shinohara; Ronald C Petersen; Dennis W Dickson; Guojun Bu
Journal:  Acta Neuropathol       Date:  2013-01-31       Impact factor: 17.088

Review 10.  Targeting estrogen receptors for the treatment of Alzheimer's disease.

Authors:  Jung Hoon Lee; Yanxialei Jiang; Dong Hoon Han; Seung Kyun Shin; Won Hoon Choi; Min Jae Lee
Journal:  Mol Neurobiol       Date:  2013-06-16       Impact factor: 5.590
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