A Suzuki1, Y Takenoshita, Y Honda, C Matsuura. 1. Department of Orthodontics, Faculty of Dentistry, Kyushu University, Fukuoka, Japan. suzuki@dent.kyushu-u.ac.jp
Abstract
OBJECTIVE: The purpose of this study was to compare the dentocraniofacial morphology of parents of children with cleft lip and/or palate (CL/P) with that of parents of children without CL/P and to use the results for genetic counseling. PARTICIPANTS: Twenty-five fathers and 40 mothers of Japanese children with CL/P, who also had relatives with CL/P within three generations (experimental group), and 413 pairs of parents of children without CL/P (control) were used in this study. To test the accuracy of the discriminant function, 165 subjects were added to this study (test group). MATERIALS AND METHODS: Sixty-five dental casts were measured by digital sliding calipers, and 1056 frontal and 1056 lateral cephalograms were traced, digitized, and analyzed using analysis of variance (ANOVA) and discriminant analysis. RESULTS: Mesiodistal tooth diameters in parents of children with CL/P did not show any differences from those in parents of children without CL/P. The parents in the experimental group showed a distinct craniofacial morphology: wider interorbital width (IO-IO'), intercoronoid process distance (Cp-Cp'), and nasal cavity width (NC-NC') and larger anterior cranial base length (S-N) and cranial base length (N-Ba). For genetic counseling, a discriminant function was obtained using four significant ratios on ANOVA. The percentage of correct classification using this function on the pooled experimental and control subjects was 67.9. CONCLUSION: The parents in the experimental group showed a special craniofacial morphology, but the results suggest that the discriminant function might not be helpful in genetic counseling.
OBJECTIVE: The purpose of this study was to compare the dentocraniofacial morphology of parents of children with cleft lip and/or palate (CL/P) with that of parents of children without CL/P and to use the results for genetic counseling. PARTICIPANTS: Twenty-five fathers and 40 mothers of Japanese children with CL/P, who also had relatives with CL/P within three generations (experimental group), and 413 pairs of parents of children without CL/P (control) were used in this study. To test the accuracy of the discriminant function, 165 subjects were added to this study (test group). MATERIALS AND METHODS: Sixty-five dental casts were measured by digital sliding calipers, and 1056 frontal and 1056 lateral cephalograms were traced, digitized, and analyzed using analysis of variance (ANOVA) and discriminant analysis. RESULTS: Mesiodistal tooth diameters in parents of children with CL/P did not show any differences from those in parents of children without CL/P. The parents in the experimental group showed a distinct craniofacial morphology: wider interorbital width (IO-IO'), intercoronoid process distance (Cp-Cp'), and nasal cavity width (NC-NC') and larger anterior cranial base length (S-N) and cranial base length (N-Ba). For genetic counseling, a discriminant function was obtained using four significant ratios on ANOVA. The percentage of correct classification using this function on the pooled experimental and control subjects was 67.9. CONCLUSION: The parents in the experimental group showed a special craniofacial morphology, but the results suggest that the discriminant function might not be helpful in genetic counseling.
Authors: S M Weinberg; S D Naidoo; K M Bardi; C A Brandon; K Neiswanger; J M Resick; R A Martin; M L Marazita Journal: Orthod Craniofac Res Date: 2009-11 Impact factor: 1.826
Authors: Dongjing Liu; Hyo-Jeong Ban; Ahmed M El Sergani; Myoung Keun Lee; Jacqueline T Hecht; George L Wehby; Lina M Moreno; Eleanor Feingold; Mary L Marazita; Seongwon Cha; Heather L Szabo-Rogers; Seth M Weinberg; John R Shaffer Journal: Front Genet Date: 2021-08-09 Impact factor: 4.599