Literature DB >> 10212393

Synthesis and antitumor activities of water-soluble benzoylphenylureas.

H Okada1, M Kato, T Koyanagi, K Mizuno.   

Abstract

Water-soluble benzoylphenylurea derivatives were synthesized as candidate prodrugs and their antitumor activities were examined in vivo against P388 leukemia. Some of the prodrugs were highly soluble in water and showed good antitumor activities against P388 leukemia cells in mice when injected intravenously.

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Year:  1999        PMID： 10212393     DOI： 10.1248/cpb.47.430

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  3 in total

1.  Liposome formulation of NSC-639829 using halothane as a solvent: a technical note.

Authors:  Akash Jain; Tapan Sanghvi; Samuel H Yalkowsky
Journal:  AAPS PharmSciTech       Date:  2003-10-15       Impact factor: 3.246

2.  Phase I study of continuous weekly dosing of dimethylamino benzoylphenylurea (BPU) in patients with solid tumours.

Authors:  Wells A Messersmith; Michelle A Rudek; Sharyn D Baker; Ming Zhao; Connie Collins; A Dimitrios Colevas; Ross C Donehower; Michael A Carducci; Antonio C Wolff
Journal:  Eur J Cancer       Date:  2006-11-03       Impact factor: 9.162

3.  Novel microtubule-interacting phenoxy pyridine and phenyl sulfanyl pyridine analogues for cancer therapy.

Authors:  Ravi Kumar Anchoori; Madeleine Susanne Quirine Kortenhorst; Manuel Hidalgo; Taradas Sarkar; Gurulingappa Hallur; Ruoli Bai; Paul J Van Diest; Ernest Hamel; Saeed R Khan
Journal:  J Med Chem       Date:  2008-09-09       Impact factor: 7.446
  3 in total

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