Insight in severe mental illness: implications for treatment decisions.

This article reviews recent research related to impaired insight in schizophrenia and its consequences for cognitive, behavioral, legal, and treatment compliance issues affecting this population. It discusses efforts to find the neurobiological basis for lack of insight and the various structures or circuits of the brain that have been implicated. In the search for a more reliable and valid measure of insight for treatment decisions, the development of various assessment instruments is summarized. Impaired insight is shown to be related to a poorer course of the illness and noncompliance with necessary treatment. The implications of these findings for treatment decisions, legal interventions, and ongoing treatment monitoring are discussed.