Literature DB >> 10210280

Growth inhibition of capsaicin on HeLa cells is not mediated by intracellular calcium mobilization.

K Takahata1, X Chen, K Monobe, M Tada.   

Abstract

The effects of capsaicin on cellular growth and intracellular calcium mobilization were examined in human cervical carcinoma derivation, HeLa cells. Capsaicin inhibited cellular growth and increased intracellular calcium level in HeLa cells. This capsaicin-induced intracellular calcium concentration rise was blocked by capsazepin, vanilloid (capsaicin) receptor antagonist. But, an intracellular calcium chelator BAPTA/AM did not block the inhibitory effect of capsaicin on cellular growth. These observations suggest that intracellular calcium mobilization is not required for the capsaicin-induced inhibition of cellular growth.

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Year:  1999        PMID： 10210280     DOI： 10.1016/s0024-3205(99)00046-6

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  5 in total

1.  MicroRNA-520a-5p displays a therapeutic effect upon chronic myelogenous leukemia cells by targeting STAT3 and enhances the anticarcinogenic role of capsaicin.

Authors:  Burçin Tezcanlı Kaymaz; Vildan Bozok Cetintaş; Cağdaş Aktan; Buket Kosova
Journal:  Tumour Biol       Date:  2014-05-30

2.  Regulation of intracellular calcium in cortical neurons transgenic for human Abeta40 and Abeta42 following nutritive challenge.

Authors:  Najeeb A Shirwany; Jun Xie; Qing Guo
Journal:  Int J Clin Exp Med       Date:  2009-06-12

3.  Effects of capsaicin on human intestinal cell line Caco-2.

Authors:  H Isoda; J Han; M Tominaga; T Maekawa
Journal:  Cytotechnology       Date:  2001-07       Impact factor: 2.058

4.  Transient receptor potential cation channel V1 (TRPV1) is degraded by starvation- and glucocorticoid-mediated autophagy.

Authors:  Seyoung Ahn; Jungyun Park; Inkyung An; Sung Jun Jung; Jungwook Hwang
Journal:  Mol Cells       Date:  2014-03-21       Impact factor: 5.034

5.  Spermatogonial stem cell sensitivity to capsaicin: an in vitro study.

Authors:  Sefika C Mizrak; Bart M Gadella; Hatice Erdost; Aytekin Ozer; Ana M M van Pelt; Federica M F van Dissel-Emiliani
Journal:  Reprod Biol Endocrinol       Date:  2008-11-14       Impact factor: 5.211
  5 in total

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