| Literature DB >> 10209663 |
F Biagi1, K P Zimmer, P D Thomas, H J Ellis, P J Ciclitira.
Abstract
The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in CD the enterocytes could metabolize gliadin through an immunogenic pathway instead of a tolerogenic one. The result of this abnormal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.Entities:
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Year: 1999 PMID： 10209663 DOI： 10.1093/qjmed/92.2.119
Source DB: PubMed Journal: QJM ISSN： 1460-2393