| Literature DB >> 10209291 |
T Bucciarelli1, P Sacchetta, A Pennelli, L Cornelio, R Romagnoli, S Melino, R Petruzzelli, C Di Ilio.
Abstract
The major form of glutathione transferase from the toad liver previously designed as Bufo bufo liver GST-7.6 (A. Aceto, B. Dragani, T. Bucciarelli, P. Sacchetta, F. Martini, S. Angelucci, F. Amicarelli, M. Miranda and C. Di Ilio, Biochem. J. 289 (1993) 417-422) has been characterized. According to its partial amino acid sequence, the toad enzyme may be included in the pi class GST and named bbGST P2-2. However, bbGST P2-2 appears to be immunologically, structurally and kinetically distinct from any other members of pi family, including bbGST P1-1, suggesting that it may constitute a subset of pi class GST. The data support the hypothesis that the transition from aquatic to terrestrial life causes a switch of the GST amphibian pattern promoting the expression of a GST form (bbGST P2-2) able to counteract, with higher efficiency, the toxic effects of reactive metabolites of oxidative metabolism and those of hydrophobic xenobiotics.Entities:
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Year: 1999 PMID： 10209291 DOI： 10.1016/s0167-4838(99)00036-9
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002