| Literature DB >> 10209160 |
Abstract
In eukaryotes, G2/M progression is mediated by activation of mitosis promoting factor (MPF). To ensure faithful chromosome segregation, the activity of key mitotic inducers and inhibitors are coupled with chromosome replication, spindle pole duplication, morphogenesis, and DNA damage. Evidence gathered in the past two years has underscored the importance of positioning MPF and its regulators in the proper place at the proper time to ensure orderly progression through the G2/M transition. Altering the spatial organization of G2/M regulators also contributes to prevention of mitosis following DNA damage.Entities:
Mesh:
Substances:
Year: 1999 PMID: 10209160 DOI: 10.1016/s0955-0674(99)80036-2
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN: 0955-0674 Impact factor: 8.382