Literature DB >> 10209156

Signalling through phosphoinositide 3-kinases: the lipids take centre stage.

S J Leevers1, B Vanhaesebroeck, M D Waterfield.   

Abstract

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids at the 3' position of the inositol ring to generate the 3-phosphoinositides PI(3)P, PI(3,4) P2 and PI(3,4,5) P3. Recent research has shown that one way in which these lipids function in signal transduction and membrane trafficking is by interacting with 3-phosphoinositide-binding modules in a broad variety of proteins. Specifically, certain FYVE domains bind PI(3)P whereas certain pleckstrin homology domains bind PI(3,4) P2 and/or PI(3,4,5) P3. Also in 1998, PTEN - a major tumour suppressor in human cancer - was also shown to antagonise PI3K signalling by removing the 3-phosphate from 3-phosphoinositides.

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Year:  1999        PMID： 10209156     DOI： 10.1016/s0955-0674(99)80029-5

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  161 in total

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3.  Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110alpha and p110beta catalytic subunits of class-Ia phosphoinositide 3-kinases.

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4.  Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein.

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5.  Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region.

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7.  Epstein-Barr virus immediate-early protein BRLF1 induces the lytic form of viral replication through a mechanism involving phosphatidylinositol-3 kinase activation.

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Journal:  J Virol       Date:  2001-07       Impact factor: 5.103

Review 8.  Natural biology of polyomavirus middle T antigen.

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9.  Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells.

Authors:  D J Gillooly; I C Morrow; M Lindsay; R Gould; N J Bryant; J M Gaullier; R G Parton; H Stenmark
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10.  Exploring the regulation of the expression of ChAT and VAChT genes in NG108-15 cells: implication of PKA and PI3K signaling pathways.

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