| Literature DB >> 10208170 |
D J Allingham-Hawkins1, R Babul-Hirji, D Chitayat, J J Holden, K T Yang, C Lee, R Hudson, H Gorwill, S L Nolin, A Glicksman, E C Jenkins, W T Brown, P N Howard-Peebles, C Becchi, E Cummings, L Fallon, S Seitz, S H Black, A M Vianna-Morgante, S S Costa, P A Otto, R C Mingroni-Netto, A Murray, J Webb, F Vieri.
Abstract
The preliminary results of an international collaborative study examining premature menopause in fragile X carriers are presented. A total of 760 women from fragile X families was surveyed about their fragile X carrier status and their menstrual and reproductive histories. Among the subjects, 395 carried a premutation, 128 carried a full mutation, and 237 were noncarriers. Sixty-three (16%) of the premutation carriers had experienced menopause prior to the age of 40 compared with none of the full mutation carriers and one (0.4%) of the controls. Based on these preliminary data, there is a significant association between fragile X premutation carrier status and premature menopause.Entities:
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Year: 1999 PMID： 10208170 PMCID： PMC3728646
Source DB: PubMed Journal: Am J Med Genet ISSN： 0148-7299