Literature DB >> 10206173

Mecamylamine-precipitated nicotine-withdrawal aversion in Lewis and Fischer 344 inbred rat strains.

T Suzuki1, Y Ise, J Maeda, M Misawa.   

Abstract

Many studies have indicated that Lewis and Fischer 344 inbred rat strains show marked differences in behavioral responses to abused drugs. In the present study, we sought to determine whether these two strains of rats show different responses in mecamylamine-precipitated nicotine-withdrawal aversion using the conditioned place preference paradigm. Rats were treated subcutaneously with 10 mg/kg/day nicotine for 7 days using an osmotic minipump. After chronic nicotine infusion, the nicotinic receptor antagonist mecamylamine produced a significant place aversion in Lewis, but not in Fischer 344 rats. These results suggest that mecamylamine-precipitated nicotine-withdrawal aversion is strongly regulated by genetic factors.

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Year:  1999        PMID： 10206173     DOI： 10.1016/s0014-2999(99)00086-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  14 in total

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7.  The role of various nicotinic receptor subunits and factors influencing nicotine conditioned place aversion.

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10.  Differential role of nicotinic acetylcholine receptor subunits in physical and affective nicotine withdrawal signs.

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