[The peptide-dependent mechanisms of long-term posttetanic potentiation (the facts and a hypothesis)].

In the article literature data and results of our studying of long-term potentiation (LTP) are analyzed the position of the proposed hypothesis that cells secrete during their activation into extracellular space a neuromodulatory factors, affecting on cell population and promoting the transformation of short-terms excitability in long-term one. It is considered the possible molecular-messengers particulated in development LTP. The neurophysiological and neurochemical evidences of the involvement neuropeptides as the key retrograde messengers are presented. It is analyzed the biological assay method as the adequate approach for study the role of endogenous neuropeptide in the LTP and analogous models. The possible mechanisms acting of neuropeptide by cells in LTP genesis are discussed.