Literature DB >> 10204864

Perfluorocarbon emulsions as intravenous delivery media for hyperpolarized xenon.

J Wolber1, I J Rowland, M O Leach, A Bifone.   

Abstract

The use of perfluorooctyl bromide (PFOB) emulsions as delivery media for hyperpolarized xenon has been investigated. Emulsion droplet size was controlled by varying the content of egg yolk phospholipid (EYP), which served as an emulsifier. Hyperpolarized 129Xe nuclear magnetic resonance (NMR) spectra of the dissolved gas were obtained. The NMR spectra were found to be correlated strongly with the emulsion droplet size distribution. The NMR line width is determined by xenon exchange between the PFOB droplets and the aqueous environment. Our findings show that, in a 1.5-Tesla field, relatively narrow 129Xe NMR spectra are obtained for droplet sizes larger than 5 microm. Preliminary results on animal models show that PFOB emulsions have potential as hyperpolarized 129Xe carriers for in vivo magnetic resonance applications.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10204864     DOI： 10.1002/(sici)1522-2594(199903)41:3<442::aid-mrm3>3.0.co;2-7

Source DB:  PubMed          Journal:  Magn Reson Med        ISSN： 0740-3194            Impact factor:   4.668


  10 in total

Review 1.  Hyperpolarized and inert gas MRI: the future.

Authors:  Marcus J Couch; Barbara Blasiak; Boguslaw Tomanek; Alexei V Ouriadov; Matthew S Fox; Krista M Dowhos; Mitchell S Albert
Journal:  Mol Imaging Biol       Date:  2015-04       Impact factor: 3.488

2.  Spin-lattice relaxation of laser-polarized xenon in human blood.

Authors:  J Wolber; A Cherubini; A S Dzik-Jurasz; M O Leach; A Bifone
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

3.  Fluorine (19F) MRS and MRI in biomedicine.

Authors:  Jesús Ruiz-Cabello; Brad P Barnett; Paul A Bottomley; Jeff W M Bulte
Journal:  NMR Biomed       Date:  2010-09-15       Impact factor: 4.044

Review 4.  Molecular Sensing with Host Systems for Hyperpolarized 129Xe.

Authors:  Jabadurai Jayapaul; Leif Schröder
Journal:  Molecules       Date:  2020-10-11       Impact factor: 4.411

Review 5.  Functionalized 129Xe contrast agents for magnetic resonance imaging.

Authors:  Olena Taratula; Ivan J Dmochowski
Journal:  Curr Opin Chem Biol       Date:  2009-11-13       Impact factor: 8.822

6.  Optical sensor arrays designed for guided manufacture of perfluorocarbon nanoemulsions with a non-synthetic stabilizer.

Authors:  Ryan Bardsley; Graeme Gardner; Hubert M Tse; Christopher A Fraker
Journal:  Acta Biomater       Date:  2021-09-24       Impact factor: 8.947

7.  Magnetic Resonance Detection of Gas Microbubbles via HyperCEST: A Path Toward Dual Modality Contrast Agent.

Authors:  Christian T McHugh; Phillip G Durham; Michele Kelley; Paul A Dayton; Rosa T Branca
Journal:  Chemphyschem       Date:  2021-05-19       Impact factor: 3.520

Review 8.  Nanoparticle-Based Contrast Agents for 129Xe HyperCEST NMR and MRI Applications.

Authors:  Jabadurai Jayapaul; Leif Schröder
Journal:  Contrast Media Mol Imaging       Date:  2019-11-22       Impact factor: 3.161

Review 9.  In vivo methods and applications of xenon-129 magnetic resonance.

Authors:  Helen Marshall; Neil J Stewart; Ho-Fung Chan; Madhwesha Rao; Graham Norquay; Jim M Wild
Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2020-12-09       Impact factor: 9.795

Review 10.  Perfluorocarbon Emulsion Contrast Agents: A Mini Review.

Authors:  Ryan Holman; Orane Lorton; Pauline C Guillemin; Stéphane Desgranges; Christiane Contino-Pépin; Rares Salomir
Journal:  Front Chem       Date:  2022-01-10       Impact factor: 5.221
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.