Literature DB >> 10203808

Telomerase activation. One step on the road to cancer?

C W Greider1.   

Abstract

Ever since the discovery that telomeres are short in cancer cells and telomerase is activated in immortal cells, telomerase has been an oncogene wannabe. Oncogenes have been the glamour genes of molecular biology for 20 years, garnering flashy headlines and name recognition. More recently, tumor-suppressor genes have joined oncogenes on center stage. Recent evidence has shown that MYC upregulates the catalytic subunit of telomerase, TERT, and that TERT cooperates with HPV E7 in cell immortalization. This evidence now supports the placement of telomerase among the cancer gene elite.

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Year:  1999        PMID： 10203808     DOI： 10.1016/s0168-9525(98)01681-3

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  19 in total

Review 1.  Small nucleolar RNAs: versatile trans-acting molecules of ancient evolutionary origin.

Authors:  Michael P Terns; Rebecca M Terns
Journal:  Gene Expr       Date:  2002

2.  DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.

Authors:  W M Tong; M P Hande; P M Lansdorp; Z Q Wang
Journal:  Mol Cell Biol       Date:  2001-06       Impact factor: 4.272

3.  Robust activation of the human but not mouse telomerase gene during the induction of pluripotency.

Authors:  Renjith Mathew; Wenwen Jia; Arati Sharma; Yuanjun Zhao; Loren E Clarke; Xiang Cheng; Huayan Wang; Ugur Salli; Kent E Vrana; Gavin P Robertson; Jiyue Zhu; Shuwen Wang
Journal:  FASEB J       Date:  2010-03-30       Impact factor: 5.191

4.  The promoter activation at the end of terminally truncated chromosome in Drosophila melanogaster.

Authors:  L S Melnikova; M V Kostyuchenko; P G Georgiev
Journal:  Dokl Biochem Biophys       Date:  2015-01-06       Impact factor: 0.788

5.  Identification of a novel transcription factor binding element involved in the regulation by differentiation of the human telomerase (hTERT) promoter.

Authors:  M Tzukerman; C Shachaf; Y Ravel; I Braunstein; O Cohen-Barak; M Yalon-Hacohen; K L Skorecki
Journal:  Mol Biol Cell       Date:  2000-12       Impact factor: 4.138

6.  Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repair.

Authors:  J P Therrien; R Drouin; C Baril; E A Drobetsky
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

7.  Value of endoscopic methylene blue and Lugol's iodine double staining and detection of GST-Pi and telomerase in the early diagnosis of esophageal carcinoma.

Authors:  Xuan Zhu; Shuang-Hong Zhang; Kun-He Zhang; Bi-Ming Li; Jiang Chen
Journal:  World J Gastroenterol       Date:  2005-10-21       Impact factor: 5.742

8.  Tel1 Activation by the MRX Complex Is Sufficient for Telomere Length Regulation but Not for the DNA Damage Response in Saccharomyces cerevisiae.

Authors:  Rebecca Keener; Carla J Connelly; Carol W Greider
Journal:  Genetics       Date:  2019-10-23       Impact factor: 4.562

9.  TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins.

Authors:  Mikhail A Nikiforov; Sanjay Chandriani; Jeonghyeon Park; Iulia Kotenko; Dina Matheos; Anna Johnsson; Steven B McMahon; Michael D Cole
Journal:  Mol Cell Biol       Date:  2002-07       Impact factor: 4.272

10.  Expression of the telomeric retrotransposon HeT-A in Drosophila melanogaster is correlated with cell proliferation.

Authors:  Marika F Walter; Harald Biessmann
Journal:  Dev Genes Evol       Date:  2004-04-07       Impact factor: 0.900
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