Literature DB >> 10203718

Antigen-based immunotherapy for autoimmune disease: from animal models to humans?

J Tian1, A Olcott, L Hanssen, D Zekzer, D L Kaufman.   

Abstract

Insights into tolerance and autoimmune processes have led to novel immunotherapeutics for inhibiting autoimmune disease in animal models. However, recent studies question the immune basis of some of these therapeutic strategies and raise concerns about their efficacy and safety. Here, we discuss the feasibility of extending the success of antigen-based immunotherapeutics for T-cell-mediated autoimmune diseases from animal models to humans.

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Year:  1999        PMID: 10203718     DOI: 10.1016/s0167-5699(99)01445-0

Source DB:  PubMed          Journal:  Immunol Today        ISSN: 0167-5699


  3 in total

Review 1.  Science, medicine, and the future: Tolerance and autoimmunity.

Authors:  I R Mackay
Journal:  BMJ       Date:  2000-07-08

2.  Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis.

Authors:  Francesca Odoardi; Naoto Kawakami; Zhaoxia Li; Chiara Cordiglieri; Kristina Streyl; Mikhail Nosov; Wolfgang E F Klinkert; Joachim W Ellwart; Jan Bauer; Hans Lassmann; Hartmut Wekerle; Alexander Flügel
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-09       Impact factor: 11.205

3.  Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens.

Authors:  Jide Tian; Hoa Dang; Harald von Boehmer; Elmar Jaeckel; Daniel L Kaufman
Journal:  Diabetes       Date:  2009-09-09       Impact factor: 9.461

  3 in total

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