Literature DB >> 10203705

FHL-1/reconectin: a human complement and immune regulator with cell-adhesive function.

P F Zipfel1, C Skerka.   

Abstract

A novel regulator of the alternative complement pathway with functions similar to that of factor H has been identified in human plasma. The cDNA encoding this factor H-like protein 1 (FHL-1/reconectin) was isolated several years ago. Here, Peter Zipfel and Christine Skerka describe functional analyses revealing that this novel complement regulatory protein forms a molecular link between immune defense and cell adhesion.

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Year:  1999        PMID： 10203705     DOI： 10.1016/s0167-5699(98)01432-7

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  52 in total

1.  Different regulation of factor H and FHL-1/reconectin by inflammatory mediators and expression of the two proteins in rheumatoid arthritis (RA).

Authors:  M A Friese; J Hellwage; T S Jokiranta; S Meri; H J Müller-Quernheim; H H Peter; H Eibel; P F Zipfel
Journal:  Clin Exp Immunol       Date:  2000-08       Impact factor: 4.330

2.  Inhibition of the alternative pathway of nonhuman infant complement by porin B2 contributes to virulence of Neisseria meningitidis in the infant rat model.

Authors:  Lisa A Lewis; David M Vu; Dan M Granoff; Sanjay Ram
Journal:  Infect Immun       Date:  2014-03-31       Impact factor: 3.441

Review 3.  CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.

Authors:  Peter F Zipfel; Thorsten Wiech; Emma D Stea; Christine Skerka
Journal:  J Am Soc Nephrol       Date:  2020-01-24       Impact factor: 10.121

4.  A case of atypical hemolytic uremic syndrome with a transient decrease in complement factor H.

Authors:  Hyewon Hahn; Eun Young Um; Young Seo Park; Hae Il Cheong
Journal:  Pediatr Nephrol       Date:  2005-12-17       Impact factor: 3.714

Review 5.  Complement regulators and inhibitory proteins.

Authors:  Peter F Zipfel; Christine Skerka
Journal:  Nat Rev Immunol       Date:  2009-09-04       Impact factor: 53.106

6.  Constitutive expression and alternative splicing of the exons encoding SCRs in Sp152, the sea urchin homologue of complement factor B. Implications on the evolution of the Bf/C2 gene family.

Authors:  David P Terwilliger; Lori A Clow; Paul S Gross; L Courtney Smith
Journal:  Immunogenetics       Date:  2004-09-22       Impact factor: 2.846

Review 7.  aHUS caused by complement dysregulation: new therapies on the horizon.

Authors:  Aoife M Waters; Christoph Licht
Journal:  Pediatr Nephrol       Date:  2010-06-18       Impact factor: 3.714

8.  Identification of an antiparallel coiled-coil/loop domain required for ligand binding by the Borrelia hermsii FhbA protein: additional evidence for the role of FhbA in the host-pathogen interaction.

Authors:  Kelley M Hovis; John C Freedman; Hongming Zhang; Jonathan L Forbes; Richard T Marconi
Journal:  Infect Immun       Date:  2008-02-25       Impact factor: 3.441

9.  Release of endogenous anti-inflammatory complement regulators FHL-1 and factor H protects synovial fibroblasts during rheumatoid arthritis.

Authors:  M A Friese; T Manuelian; S Junnikkala; J Hellwage; S Meri; H H Peter; D L Gordon; H Eibel; P F Zipfel
Journal:  Clin Exp Immunol       Date:  2003-06       Impact factor: 4.330

10.  Haemolytic uraemic syndrome and mutations of the factor H gene: a registry-based study of German speaking countries.

Authors:  H P H Neumann; M Salzmann; B Bohnert-Iwan; T Mannuelian; C Skerka; D Lenk; B U Bender; M Cybulla; P Riegler; A Königsrainer; U Neyer; A Bock; U Widmer; D A Male; G Franke; P F Zipfel
Journal:  J Med Genet       Date:  2003-09       Impact factor: 6.318
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