| Literature DB >> 10203704 |
Abstract
Autoimmune diseases are characterized by multiple autoantibodies and/or autoreactive T cells that recognize a large number of antigens. Many of these antigens undergo extensive post-translational modifications during apoptosis and act as substrates for the proapoptotic cystein proteases. Here, Mauro Piacentini and Vittorio Colizzi discuss the effects on autoimmunity produced by post-translational modifications of proteins catalysed by the proapoptotic enzyme tissue transglutaminase.Entities:
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Year: 1999 PMID: 10203704 DOI: 10.1016/s0167-5699(98)01416-9
Source DB: PubMed Journal: Immunol Today ISSN: 0167-5699