Literature DB >> 10203523

Second generation of the automated Cobas Amplicor HCV assay improves sensitivity of hepatitis C virus RNA detection and yields results that are more clinically relevant.

A Doglio1, C Laffont, F X Caroli-Bosc, P Rochet, J Lefebvre.   

Abstract

The first and second generations of the Cobas Amplicor HCV assay were compared among patients at risk of hepatitis C virus (HCV) infection. The second-generation test was found to be of greater sensitivity and of good specificity among clinical specimens containing HCV RNA of different genotypes. Finally, this new test is shown to predict the outcome of interferon therapy better.

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Year:  1999        PMID： 10203523      PMCID： PMC84830     

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  11 in total

1.  COBAS AMPLICOR: fully automated RNA and DNA amplification and detection system for routine diagnostic PCR.

Authors:  N DiDomenico; H Link; R Knobel; T Caratsch; W Weschler; Z G Loewy; M Rosenstraus
Journal:  Clin Chem       Date:  1996-12       Impact factor: 8.327

Review 2.  Factors predictive of a beneficial response to therapy of hepatitis C.

Authors:  G L Davis; J Y Lau
Journal:  Hepatology       Date:  1997-09       Impact factor: 17.425

3.  Use of uracil DNA glycosylase to control carry-over contamination in polymerase chain reactions.

Authors:  M C Longo; M S Berninger; J L Hartley
Journal:  Gene       Date:  1990-09-01       Impact factor: 3.688

4.  Evaluation of automated COBAS AMPLICOR PCR system for detection of several infectious agents and its impact on laboratory management.

Authors:  D Jungkind; S Direnzo; K G Beavis; N S Silverman
Journal:  J Clin Microbiol       Date:  1996-11       Impact factor: 5.948

5.  Monitoring of serum levels of HCV RNA in early phase of IFN therapy; as a predictive marker of subsequent response.

Authors:  Y Yamakawa; M Sata; H Suzuki; K Tanaka; E Tanaka; S Noguchi; K Ono; K Tanikawa
Journal:  Hepatogastroenterology       Date:  1998 Jan-Feb

6.  Multicenter evaluation of the COBAS AMPLICOR HCV assay, an integrated PCR system for rapid detection of hepatitis C virus RNA in the diagnostic laboratory.

Authors:  J Albadalejo; R Alonso; R Antinozzi; M Bogard; A M Bourgault; G Colucci; T Fenner; H Petersen; E Sala; J Vincelette; C Young
Journal:  J Clin Microbiol       Date:  1998-04       Impact factor: 5.948

7.  Prediction of response during interferon alfa 2b therapy in chronic hepatitis C patients using viral and biochemical characteristics: a comparison.

Authors:  M J Tong; L M Blatt; J G McHutchison; R L Co; A Conrad
Journal:  Hepatology       Date:  1997-12       Impact factor: 17.425

8.  Clinical evaluation of a single reaction, diagnostic polymerase chain reaction assay for the detection of hepatitis C virus RNA.

Authors:  G Gerken; P Pontisso; M Roggendorf; M Grazia Rumi; P Simmonds; C Trepo; S Zeuzem; G Colucci
Journal:  J Hepatol       Date:  1996-01       Impact factor: 25.083

9.  Rapid genotyping of hepatitis C virus by direct cycle sequencing of PCR-amplified cDNAs and capillary electrophoresis analysis.

Authors:  A Doglio; C Laffont; S Thyss; J C Lefebvre
Journal:  Res Virol       Date:  1998 Jul-Aug

10.  Detection of hepatitis C virus RNA by a combined reverse transcription-polymerase chain reaction assay.

Authors:  K K Young; R M Resnick; T W Myers
Journal:  J Clin Microbiol       Date:  1993-04       Impact factor: 5.948
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  13 in total

1.  Effects of storage and type of blood collection tubes on hepatitis C virus level in whole blood samples.

Authors:  H H Kessler; E Stelzl; R B Raggam; J Haas; F Kirchmeir; K Hegenbarth; E Daghofer; B I Santner; E Marth; R E Stauber
Journal:  J Clin Microbiol       Date:  2001-05       Impact factor: 5.948

2.  Assessment of viral loads in patients with chronic hepatitis C with AMPLICOR HCV MONITOR version 1.0, COBAS HCV MONITOR version 2.0, and QUANTIPLEX HCV RNA version 2.0 assays.

Authors:  M Martinot-Peignoux; V Le Breton; S Fritsch; G Le Guludec; N Labouret; F Keller; P Marcellin
Journal:  J Clin Microbiol       Date:  2000-07       Impact factor: 5.948

3.  Assessment, by transcription-mediated amplification, of virologic response in patients with chronic hepatitis C virus treated with peginterferon alpha-2a.

Authors:  C Sarrazin; D A Hendricks; F Sedarati; S Zeuzem
Journal:  J Clin Microbiol       Date:  2001-08       Impact factor: 5.948

4.  Prospective multicenter clinical evaluation of AMPLICOR and COBAS AMPLICOR hepatitis C virus tests.

Authors:  F S Nolte; M W Fried; M L Shiffman; A Ferreira-Gonzalez; C T Garrett; E R Schiff; S J Polyak; D R Gretch
Journal:  J Clin Microbiol       Date:  2001-11       Impact factor: 5.948

5.  Evaluation of the VERSANT HCV RNA 3.0 assay for quantification of hepatitis C virus RNA in serum.

Authors:  Pascale Trimoulet; Philippe Halfon; Eric Pohier; Hacène Khiri; Geneviève Chêne; Hervé Fleury
Journal:  J Clin Microbiol       Date:  2002-06       Impact factor: 5.948

6.  Performance characteristics of a transcription-mediated nucleic acid amplification assay for qualitative detection of hepatitis C virus RNA.

Authors:  R S Ross; S O Viazov; S Hoffmann; M Roggendorf
Journal:  J Clin Lab Anal       Date:  2001       Impact factor: 2.352

7.  Performance characteristics of a quantitative, homogeneous TaqMan RT-PCR test for HCV RNA.

Authors:  J Kleiber; T Walter; G Haberhausen; S Tsang; R Babiel; M Rosenstraus
Journal:  J Mol Diagn       Date:  2000-08       Impact factor: 5.568

8.  Therapy for treatment-refractory chronic hepatitis C virus genotype 1b infection: A retrospective analysis.

Authors:  Mehmet Cindoruk; Tarkan Karakan; Selahattin Unal
Journal:  Curr Ther Res Clin Exp       Date:  2005-09

9.  Clinical evaluation of the automated COBAS AMPLICOR HCV MONITOR test version 2.0 for quantifying serum hepatitis C virus RNA and comparison to the quantiplex HCV version 2.0 test.

Authors:  M L Yu; W L Chuang; C Y Dai; S C Chen; Z Y Lin; M Y Hsieh; L Y Wang; W Y Chang
Journal:  J Clin Microbiol       Date:  2000-08       Impact factor: 5.948

10.  Qualitative detection of hepatitis C virus RNA: comparison of analytical sensitivity, clinical performance, and workflow of the Cobas Amplicor HCV test version 2.0 and the HCV RNA transcription-mediated amplification qualitative assay.

Authors:  Mel Krajden; Rainer Ziermann; Asphani Khan; Annie Mak; Kimmy Leung; David Hendricks; Lorraine Comanor
Journal:  J Clin Microbiol       Date:  2002-08       Impact factor: 5.948
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