Literature DB >> 10203473

Age-dependent acquisition of hepatitis G virus/GB virus C in a nonrisk population: detection of the virus by antibodies.

H H Feucht1, M Schröter, B Zöllner, S Polywka, R Laufs.   

Abstract

Until now there have been few seroepidemiological data for hepatitis G virus/GB virus type C (HGV/GBV-C). A four-antigen HGV/GBV-C immunoblot was established to examine 446 serum specimens from healthy individuals without risk factors for parenteral viral transmission. These individuals were divided into seven groups according to age. Seroprevalence rates were low for children and adolescents (5.6%) and increased for the age groups assumed to be the most sexually active (15.3 to 26.8%). Remarkably, none of the 80 individuals who tested positive for HGV/GBV-C antibodies were simultaneously positive for HGV/GBV-C viremia. From our data we conclude that HGV/GBV-C infection is widespread in the general population (16 to 25%). The development of an antibody response is associated with clearance of HGV/GBV-C viremia. Due to the lack of risk factors for HGV/GBV-C infection of blood, other efficient transmission routes must exist. It must be assumed that HGV/GBV-C transmission may be linked to sexual activity.

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Year:  1999        PMID： 10203473      PMCID： PMC84755     

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  24 in total

1.  Distribution of hepatitis G viremia and antibody response to recombinant proteins with special regard to risk factors in 709 patients.

Authors:  H H Feucht; B Zöllner; S Polywka; B Knödler; M Schröter; H Nolte; R Laufs
Journal:  Hepatology       Date:  1997-08       Impact factor: 17.425

2.  Herpes simplex virus type 2 in the United States, 1976 to 1994.

Authors:  D T Fleming; G M McQuillan; R E Johnson; A J Nahmias; S O Aral; F K Lee; M E St Louis
Journal:  N Engl J Med       Date:  1997-10-16       Impact factor: 91.245

3.  Parenteral and sexual transmission of GB virus C and hepatitis C virus among human immunodeficiency virus-positive patients.

Authors:  G Fiordalisi; A Bettinardi; I Zanella; R Stellini; G Paraninfo; G Cadeo; D Primi
Journal:  J Infect Dis       Date:  1997-04       Impact factor: 5.226

4.  Prevalence and infectivity of hepatitis G virus and its strain variant, the GB agent, in volunteer blood donors in Taiwan.

Authors:  J T Wang; P J Chen; D P Liu; J C Sheu; T H Wang; D S Chen
Journal:  Transfusion       Date:  1998-03       Impact factor: 3.157

5.  Prevalence of antibodies against varicella zoster, herpes simplex (types 1 and 2), hepatitis B and hepatitis A viruses among Spanish adolescents.

Authors:  A Gil; A González; R Dal-Ré; P Ortega; V Dominguez
Journal:  J Infect       Date:  1998-01       Impact factor: 6.072

6.  Expression of the GB virus C E2 glycoprotein using the Semliki Forest virus vector system and its utility as a serologic marker.

Authors:  T J Pilot-Matias; R J Carrick; P F Coleman; T P Leary; T K Surowy; J N Simons; A S Muerhoff; S L Buijk; M L Chalmers; G J Dawson; S M Desai; I K Mushahwar
Journal:  Virology       Date:  1996-11-15       Impact factor: 3.616

7.  Detection of the hepatitis G virus genome among injecting drug users, homosexual and bisexual men, and blood donors.

Authors:  K Stark; U Bienzle; G Hess; A M Engel; B Hegenscheid; V Schluter
Journal:  J Infect Dis       Date:  1996-12       Impact factor: 5.226

8.  Sexual transmission of GB virus C/hepatitis G virus.

Authors:  M F Scallan; D Clutterbuck; L M Jarvis; G R Scott; P Simmonds
Journal:  J Med Virol       Date:  1998-07       Impact factor: 2.327

9.  Sequence and genomic organization of GBV-C: a novel member of the flaviviridae associated with human non-A-E hepatitis.

Authors:  T P Leary; A S Muerhoff; J N Simons; T J Pilot-Matias; J C Erker; M L Chalmers; G G Schlauder; G J Dawson; S M Desai; I K Mushahwar
Journal:  J Med Virol       Date:  1996-01       Impact factor: 2.327

10.  Prevalence and genotypes of GB virus C/hepatitis G virus (GBV-C/HGV) and hepatitis C virus among patients infected with human immunodeficiency virus: evidence of GBV-C/HGV sexual transmission.

Authors:  A Ibáñez; M Giménez-Barcons; A Tajahuerce; C Tural; G Sirera; B Clotet; J M Sánchez-Tapias; J Rodés; M A Martínez; J C Saiz
Journal:  J Med Virol       Date:  1998-08       Impact factor: 2.327
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  3 in total

1.  Role of GB virus C in HIV-1-infected and hepatitis C virus-infected hemophiliac children and adolescents.

Authors:  Solveig Tenckhoff; Thorsten Kaiser; Fritz Bredeek; Sharyne Donfield; Erika Menius; Alice Lail; Joachim Mössner; Eric S Daar; Hans L Tillmann
Journal:  J Acquir Immune Defic Syndr       Date:  2012-10-01       Impact factor: 3.731

2.  HIV-1 fusion is blocked through binding of GB Virus C E2-derived peptides to the HIV-1 gp41 disulfide loop [corrected].

Authors:  Kristin Eissmann; Sebastian Mueller; Heinrich Sticht; Susan Jung; Peng Zou; Shibo Jiang; Andrea Gross; Jutta Eichler; Bernhard Fleckenstein; Heide Reil
Journal:  PLoS One       Date:  2013-01-22       Impact factor: 3.240

3.  GB virus type C E2 protein inhibits human immunodeficiency virus type 1 Gag assembly by downregulating human ADP-ribosylation factor 1.

Authors:  Chenliang Wang; Christine L Timmons; Qiujia Shao; Ballington L Kinlock; Tiffany M Turner; Aikichi Iwamoto; Hui Zhang; Huanliang Liu; Bindong Liu
Journal:  Oncotarget       Date:  2015-12-22
  3 in total

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