| Literature DB >> 10203250 |
F Wavrant-DeVrièze1, V Rudrasingham, J C Lambert, S Chakraverty, P Kehoe, R Crook, P Amouyel, W Wu, P Holmans, F Rice, J Pérez-Tur, B Frigard, J C Morris, S Carty, D Cottel, N Tunstall, S Lovestone, R C Petersen, M C Chartier-Harlin, A Goate, M J Owen, J Williams, J Hardy.
Abstract
Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.Entities:
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Year: 1999 PMID： 10203250 DOI： 10.1016/s0304-3940(99)00035-x
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046