Literature DB >> 10203244

Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter.

A Rioux1, V Fabre, K P Lesch, R Moessner, D L Murphy, L Lanfumey, M Hamon, M P Martres.   

Abstract

The serotonin transporter (5-HTT) plays a key-role in the control of serotoninergic neurotransmission and is the target of some antidepressants. Possible adaptive changes in brain 5-HT2A receptors were investigated in knock-out mice that do not express the 5-HTT. Autoradiographic labeling of these receptors by the selective antagonist [3H]MDL 100,907 and saturation experiments with cortical membranes revealed: (1) a new localization of these receptors in the external field of striatum (possibly in striosomes); (2) regional variations in adaptive changes in the density of 5-HT2A receptors in 5-HT(-/-) mutants (-30-40% in the claustrum, cerebral cortex and lateral striatum; no significant change in the striatum core) as compared to wild-type mice.

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Year:  1999        PMID： 10203244     DOI： 10.1016/s0304-3940(99)00049-x

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


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