S K Singhal1, S B Mann, U Datta, N K Panda, A K Gupta. 1. Department of Otolaryngology and Head & Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Abstract
PURPOSE: The aim of this study was to determine the relationship of HLA typing in patients with otosclerosis. MATERIALS AND METHODS: We used a prospective study in which HLA typing of 100 surgically confirmed otosclerosis patients were compared with age and sex matched normal individuals. RESULTS: HLA-A3, HLA-A9, HLA-A11, and HLA-B13 were found to be significantly higher (P < .05, .01, and .01, respectively). HLA-A9 and HLA-A11 were found to be higher (P < .01) in patients with a positive family history, indicating genetic heterogenicity. CONCLUSIONS: Higher values of HLA-A9, HLA-11, and HLA-B13 in patients with otosclerosis compared with normal individuals strongly suggests a genetic, HLA-related component.
PURPOSE: The aim of this study was to determine the relationship of HLA typing in patients with otosclerosis. MATERIALS AND METHODS: We used a prospective study in which HLA typing of 100 surgically confirmed otosclerosispatients were compared with age and sex matched normal individuals. RESULTS: HLA-A3, HLA-A9, HLA-A11, and HLA-B13 were found to be significantly higher (P < .05, .01, and .01, respectively). HLA-A9 and HLA-A11 were found to be higher (P < .01) in patients with a positive family history, indicating genetic heterogenicity. CONCLUSIONS: Higher values of HLA-A9, HLA-11, and HLA-B13 in patients with otosclerosis compared with normal individuals strongly suggests a genetic, HLA-related component.
Authors: W Chen; C A Campbell; G E Green; K Van Den Bogaert; C Komodikis; L S Manolidis; E Aconomou; Y Kyamides; K Christodoulou; C Faghel; C M Giguére; R L Alford; S Manolidis; G Van Camp; R J H Smith Journal: J Med Genet Date: 2002-07 Impact factor: 6.318
Authors: Bharath Wootla; Aleksandar Denic; Jens O Watzlawik; Arthur E Warrington; Laurie J Zoecklein; Louisa M Papke-Norton; Chella David; Moses Rodriguez Journal: J Neuroinflammation Date: 2016-11-17 Impact factor: 8.322