Literature DB >> 10203050

Live attenuated SIV--a model of a vaccine for AIDS.

N Almond1, J Stott.   

Abstract

The experimental infection of macaques with simian immunodeficiency virus (SIV) has provided strong evidence that it may be possible to develop a vaccine against AIDS. Live attenuated SIV vaccines have been found to confer the most potent protection against challenge with a variety of pathogenic viruses. This article summarizes the work performed at NIBSC to characterize the protection conferred by live attenuated SIV and to identify mechanisms of vaccine protection. The results of these experiments are discussed in conjunction with observations from related studies made by other groups.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10203050     DOI： 10.1016/s0165-2478(98)00153-9

Source DB:  PubMed          Journal:  Immunol Lett        ISSN： 0165-2478            Impact factor:   3.685


  12 in total

1.  Mhc haplotype H6 is associated with sustained control of SIVmac251 infection in Mauritian cynomolgus macaques.

Authors:  Edward T Mee; Neil Berry; Claire Ham; Ulrike Sauermann; Maria T Maggiorella; Frédéric Martinon; Ernst J Verschoor; Jonathan L Heeney; Roger Le Grand; Fausto Titti; Neil Almond; Nicola J Rose
Journal:  Immunogenetics       Date:  2009-04-01       Impact factor: 2.846

2.  Envelope variation as a primary determinant of lentiviral vaccine efficacy.

Authors:  Jodi K Craigo; Baoshan Zhang; Shannon Barnes; Tara L Tagmyer; Sheila J Cook; Charles J Issel; Ronald C Montelaro
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-10       Impact factor: 11.205

3.  Live attenuated HIV vaccines: predicting the tradeoff between efficacy and safety.

Authors:  S M Blower; K Koelle; D E Kirschner; J Mills
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-13       Impact factor: 11.205

4.  Immune suppression of challenged vaccinates as a rigorous assessment of sterile protection by lentiviral vaccines.

Authors:  Jodi K Craigo; Shannon Durkin; Timothy J Sturgeon; Tara Tagmyer; Sheila J Cook; Charles J Issel; Ronald C Montelaro
Journal:  Vaccine       Date:  2006-09-22       Impact factor: 3.641

5.  In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail.

Authors:  P N Fultz; P J Vance; M J Endres; B Tao; J D Dvorin; I C Davis; J D Lifson; D C Montefiori; M Marsh; M H Malim; J A Hoxie
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

6.  Divergence, not diversity of an attenuated equine lentivirus vaccine strain correlates with protection from disease.

Authors:  Jodi K Craigo; Shannon Barnes; Sheila J Cook; Charles J Issel; Ronald C Montelaro
Journal:  Vaccine       Date:  2010-10-16       Impact factor: 3.641

7.  AIDS vaccination studies using an ex vivo feline immunodeficiency virus model: protection from an intraclade challenge administered systemically or mucosally by an attenuated vaccine.

Authors:  Mauro Pistello; Donatella Matteucci; Francesca Bonci; Patrizia Isola; Paola Mazzetti; Lucia Zaccaro; Antonio Merico; Daniela Del Mauro; Norman Flynn; Mauro Bendinelli
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

8.  Vaccination of rhesus macaques with a vif-deleted simian immunodeficiency virus proviral DNA vaccine.

Authors:  Ellen E Sparger; Robert A Dubie; Barbara L Shacklett; Kelly S Cole; W L Chang; Paul A Luciw
Journal:  Virology       Date:  2008-02-07       Impact factor: 3.616

9.  Envelope determinants of equine lentiviral vaccine protection.

Authors:  Jodi K Craigo; Corin Ezzelarab; Sheila J Cook; Liu Chong; David Horohov; Charles J Issel; Ronald C Montelaro
Journal:  PLoS One       Date:  2013-06-13       Impact factor: 3.240

10.  Allogeneic lymphocyte transfer in MHC-identical siblings and MHC-identical unrelated Mauritian cynomolgus macaques.

Authors:  Edward T Mee; Richard Stebbings; Joanna Hall; Elaine Giles; Neil Almond; Nicola J Rose
Journal:  PLoS One       Date:  2014-02-11       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.