| Literature DB >> 10201844 |
D R Luthin1, A K Rabinovich, D R Bhumralkar, K L Youngblood, R A Bychowski, D S Dhanoa, J M May.
Abstract
A novel series of derivatives of oxo-7H-benzo[e]perimidine-4-carboxylic acid (I) potently displaced radioligand binding of 125I-CRF to both CRF1 and CRF2 receptors. The members of this series antagonized CRF-stimulated cAMP formation and CRF-stimulated corticotropin release from rat pituitary in vivo. These are the first nonpeptide antagonists to show activity at both CRF1 and CRF2 receptors.Entities:
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Year: 1999 PMID： 10201844 DOI： 10.1016/s0960-894x(99)00075-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823