| Literature DB >> 10201842 |
E M Naylor1, E R Parmee, V J Colandrea, L Perkins, L Brockunier, M R Candelore, M A Cascieri, L F Colwell, L Deng, W P Feeney, M J Forrest, G J Hom, D E MacIntyre, C D Strader, L Tota, P R Wang, M J Wyvratt, M H Fisher, A E Weber.
Abstract
The cyclopentylpropylimidazolidinone L-766,892 is a potent beta3 AR agonist (EC50 5.7 nM, 64% activation) with 420- and 130-fold selectivity over binding to the beta1 and beta2 ARs, respectively. In anesthetized rhesus monkeys, L-766,892 elicited dose-dependent hyperglycerolemia (ED50 0.1 mg/kg) with minimal effects on heart rate.Entities:
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Year: 1999 PMID： 10201842 DOI： 10.1016/s0960-894x(99)00072-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823