| Literature DB >> 10201828 |
R W Ratcliffe1, R R Wilkening, K J Wildonger, S T Waddell, G M Santorelli, D L Parker, J D Morgan, T A Blizzard, M L Hammond, J V Heck, J Huber, J Kohler, K L Dorso, E St Rose, J G Sundelof, W J May, G G Hammond.
Abstract
A series of 1beta-methyl-2-(naphthosultamyl)methyl-carbapenems bearing dicationic groups on the naphthosultamyl moiety was prepared and evaluated for activity against resistant gram-positive bacteria. Based on a combination of excellent in vitro antibacterial activity, acceptable mouse acute toxicity, and a desirable fragmentation pattern on beta-lactam ring opening, the analog 2g (L-786,392) was selected for extended evaluation.Entities:
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Year: 1999 PMID： 10201828 DOI： 10.1016/s0960-894x(99)00071-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823