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Literature DB >> 10200530

Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation.

C Fiorentini¹, M Gauthier, G Donelli, P Boquet.

Abstract

In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed. Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects on Rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis.

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Year: 1998 PMID： 10200530 DOI： 10.1038/sj.cdd.4400412

Source DB: PubMed Journal: Cell Death Differ ISSN： 1350-9047 Impact factor: 15.828

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Cited

8 in total

1. The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal.

Authors: M Le Gall; J C Chambard; J P Breittmayer; D Grall; J Pouysségur; E Van Obberghen-Schilling
Journal: Mol Biol Cell Date: 2000-03 Impact factor: 4.138

2. Dissecting the role of Rho-mediated signaling in contractile ring formation.

Authors: Keiju Kamijo; Naoya Ohara; Mitsuhiro Abe; Takashi Uchimura; Hiroshi Hosoya; Jae-Seon Lee; Toru Miki
Journal: Mol Biol Cell Date: 2005-10-19 Impact factor: 4.138

3. Regulation of Apoptosis by Gram-Positive Bacteria: Mechanistic Diversity and Consequences for Immunity.

Authors: Glen C Ulett; Elisabeth E Adderson
Journal: Curr Immunol Rev Date: 2006-05

4. Tyrosine phosphorylation of the vascular endothelial-growth-factor receptor-2 (VEGFR-2) is modulated by Rho proteins.

Authors: D Gingras; S Lamy; R Béliveau
Journal: Biochem J Date: 2000-06-01 Impact factor: 3.857

5. Genome comparison of the epiphytic bacteria Erwinia billingiae and E. tasmaniensis with the pear pathogen E. pyrifoliae.

Authors: Michael Kube; Alexander M Migdoll; Isabel Gehring; Katja Heitmann; Yvonne Mayer; Heiner Kuhl; Florian Knaust; Klaus Geider; Richard Reinhardt
Journal: BMC Genomics Date: 2010-06-22 Impact factor: 3.969

Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation.

1. The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal.

2. Dissecting the role of Rho-mediated signaling in contractile ring formation.

3. Regulation of Apoptosis by Gram-Positive Bacteria: Mechanistic Diversity and Consequences for Immunity.

4. Tyrosine phosphorylation of the vascular endothelial-growth-factor receptor-2 (VEGFR-2) is modulated by Rho proteins.

5. Genome comparison of the epiphytic bacteria Erwinia billingiae and E. tasmaniensis with the pear pathogen E. pyrifoliae.

6. Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells.

7. Rho-dependent regulation of cell spreading by the tetraspan membrane protein Gas3/PMP22.

Review 8. Untying the Gordian knot of cytokinesis. Role of small G proteins and their regulators.