| Literature DB >> 10200486 |
S L Schendel1, M Montal, J C Reed.
Abstract
The Bcl-2 protein family function(s) as important regulators of cellular decisions to heed or ignore death signals. The three-dimensional structure of the Bcl-2 homolog, Bcl-XL, bears a strong resemblance to some pore-forming bacterial toxins. This similarity suggested that the Bcl-2 family proteins may also possess channel-forming capability. This review summarizes the recent initial studies on the in vitro channel activity of Bcl-2, Bcl-XL and Bax and offers some speculation as to the physiological role that these channels may play in the cell death pathway.Entities:
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Year: 1998 PMID： 10200486 DOI： 10.1038/sj.cdd.4400365
Source DB: PubMed Journal: Cell Death Differ ISSN： 1350-9047 Impact factor: 15.828