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Literature DB >> 10200413

Molecular insights into the physiology of the 'thin film' of airway surface liquid.

Abstract

The epithelia that line the airways of the lung exhibit two general functions: (1) airway epithelia in all regions 'defend' the lung against infectious and noxious agents; and (2) airway epithelia in the proximal regions replenish water lost from airway surfaces, i.e. the 'insensible water loss', consequent to conditioning inspired air. How airway epithelia perform both functions, and co-ordinate them in health and disease, is the subject of this review.

Entities: Chemical Disease

Mesh：

Year: 1999 PMID： 10200413 PMCID： PMC2269304 DOI： 10.1111/j.1469-7793.1999.0631u.x

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

28 in total

1. Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4.

Authors: T Ma; B Yang; A Gillespie; E J Carlson; C J Epstein; A S Verkman
Journal: J Clin Invest Date: 1997-09-01 Impact factor: 14.808

2. Plasma membrane water permeability of cultured cells and epithelia measured by light microscopy with spatial filtering.

Authors: J Farinas; M Kneen; M Moore; A S Verkman
Journal: J Gen Physiol Date: 1997-09 Impact factor: 4.086

Review 3. The aquaporin family of water channel proteins in clinical medicine.

Authors: M D Lee; L S King; P Agre
Journal: Medicine (Baltimore) Date: 1997-05 Impact factor: 1.889

Review 4. Human airway ion transport. Part one.

Authors: R C Boucher
Journal: Am J Respir Crit Care Med Date: 1994-07 Impact factor: 21.405

5. Selective response of human airway epithelia to luminal but not serosal solution hypertonicity. Possible role for proximal airway epithelia as an osmolality transducer.

Authors: N J Willumsen; C W Davis; R C Boucher
Journal: J Clin Invest Date: 1994-08 Impact factor: 14.808

6. Na+/K+ ATPase in lower airway epithelium from cystic fibrosis and non-cystic-fibrosis lung.

Authors: D Peckham; E Holland; S Range; A J Knox
Journal: Biochem Biophys Res Commun Date: 1997-03-17 Impact factor: 3.575

7. CFTR as a cAMP-dependent regulator of sodium channels.

Authors: M J Stutts; C M Canessa; J C Olsen; M Hamrick; J A Cohn; B C Rossier; R C Boucher
Journal: Science Date: 1995-08-11 Impact factor: 47.728

8. Defective regulation of outwardly rectifying Cl- channels by protein kinase A corrected by insertion of CFTR.

Authors: M Egan; T Flotte; S Afione; R Solow; P L Zeitlin; B J Carter; W B Guggino
Journal: Nature Date: 1992-08-13 Impact factor: 49.962

9. Altered fluid transport across airway epithelium in cystic fibrosis.

Authors: C Jiang; W E Finkbeiner; J H Widdicombe; P B McCray; S S Miller
Journal: Science Date: 1993-10-15 Impact factor: 47.728

10. Tracheal vascular response to hypertonic and hypotonic solutions.

Authors: J Prazma; C C Coleman; W W Shockley; R C Boucher
Journal: J Appl Physiol (1985) Date: 1994-06

46 in total

Review 1. Infection control in cystic fibrosis: methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and the Burkholderia cepacia complex.

Authors: J R Govan
Journal: J R Soc Med Date: 2000 Impact factor: 5.344

Molecular insights into the physiology of the 'thin film' of airway surface liquid.

1. Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4.

2. Plasma membrane water permeability of cultured cells and epithelia measured by light microscopy with spatial filtering.

Review 3. The aquaporin family of water channel proteins in clinical medicine.

Review 4. Human airway ion transport. Part one.

5. Selective response of human airway epithelia to luminal but not serosal solution hypertonicity. Possible role for proximal airway epithelia as an osmolality transducer.

6. Na+/K+ ATPase in lower airway epithelium from cystic fibrosis and non-cystic-fibrosis lung.

7. CFTR as a cAMP-dependent regulator of sodium channels.

8. Defective regulation of outwardly rectifying Cl- channels by protein kinase A corrected by insertion of CFTR.

9. Altered fluid transport across airway epithelium in cystic fibrosis.

10. Tracheal vascular response to hypertonic and hypotonic solutions.

Review 1. Infection control in cystic fibrosis: methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and the Burkholderia cepacia complex.

Review 2. Pathogenesis of cystic fibrosis airways disease.

3. Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3.

Review 4. Mucus clearance as a primary innate defense mechanism for mammalian airways.

5. Noninvasive in vivo fluorescence measurement of airway-surface liquid depth, salt concentration, and pH.

6. A new approach to epithelial isotonic fluid transport: an osmosensor feedback model.

Review 7. Mechanisms of acid and base secretion by the airway epithelium.

8. Nucleotide regulation of paracellular Cl- permeability in natural rabbit airway epithelium.

Review 9. Innate host defense of the lung: effects of lung-lining fluid pH.

10. Paracrine potential of fibroblasts exposed to cigarette smoke extract with vascular growth factor induction.